Eurycoma harmandiana
Eurycoma harmandiana
Eurycoma harmandiana，这种植物在某些亚洲文化中传统上被使用，但没有具体的传统用途记录。现代科学研究表明其根部含有如chaparrinone和canthin-6-one等喹桑内酯类化合物，并且具有对抗HCoV-OC43和SARS-CoV-2病毒的抗病毒活性。此外，这些化合物还显示出PDE-5抑制作用，分子对接研究表明可能与SARS-CoV-2蛋白酶存在潜在相互作用。然而，目前的科学证据有限，需要进一步研究来确认这些发现。Eurycoma harmandiana没有记录到主要的安全问题或药物相互作用，但由于当前研究的初步性质，仍需进行更多调查。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 厄罗多纳木根及其奎桑内酯，尤其是查帕里诺酮，在细胞内ELISA试验中对HCoV-OC43和SARS-CoV-2显示出强大的抗病毒活性。
- 研究发现，厄罗科马·哈曼迪安娜根中的canthin-6-one生物碱表现出PDE-5抑制活性。
- 分子对接和模拟研究表明，厄鲁科玛·哈曼迪亚中的칸틴-6-온 9-O-β-葡萄吡喃糖苷可能与SARS-CoV-2蛋白酶相互作用。
- 该研究比较了微胶束液相色谱（MLC）和常规HPLC分析Eurycoma spp.提取物中的canthin-6-one生物碱，发现两种方法均可比，但当浓度较低时HPLC略胜一筹。
Frequently asked questions
What is Eurycoma harmandiana?
Eurycoma harmandiana (Eurycoma harmandiana) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Eurycoma harmandiana?
4 sourced findings are recorded for Eurycoma harmandiana; the strongest carries evidence grade D. For example: 厄罗多纳木根及其奎桑内酯，尤其是查帕里诺酮，在细胞内ELISA试验中对HCoV-OC43和SARS-CoV-2显示出强大的抗病毒活性。
How strong is the evidence for Eurycoma harmandiana?
The strongest finding for Eurycoma harmandiana carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Eurycoma harmandiana safe? What are the side effects?
No major safety issues are recorded for Eurycoma harmandiana in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Eurycoma harmandiana interact with medications?
No drug interactions are recorded for Eurycoma harmandiana in our sources. This does not rule them out — check with a pharmacist.
Is Eurycoma harmandiana a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/ 3CLpro: molecular docking and simulation studies of three pertinent medicinal plant natural components. literature abstract metadata
- T2 Phosphodiesterase-5 Inhibitory Activity of Canthin-6-One Alkaloids and the Roots of Eurycoma longifolia and Eurycoma harmandiana. literature abstract metadata
- T2 Evaluating the in Vitro Efficacy of Quassinoids from Eurycoma longifolia and Eurycoma harmandiana against Common Cold Human Coronavirus OC43 and SARS-CoV-2 Using In-Cell Enzyme-Linked Immunosorbent Assay. literature abstract metadata
- T2 Analysis of canthin-6-one alkaloids derived from Eurycoma spp. by micellar liquid chromatography and conventional high-performance liquid chromatography: a comparative evaluation. literature abstract metadata