Gnetum leptostachyum
Gnetum leptostachyum
Gnetum leptostachyum 是一种传统使用的草本植物，但文献有限。科学证据表明其活性成分（如异奎酚苷，ISO）对肺损伤和神经功能缺陷具有潜在保护作用。ISO 在大鼠脑缺血/再灌注后显示出剂量相关的梗死体积和神经损伤减轻，可能通过激活 PI3K/Akt 通路实现。此外，该植物的另一种成分异罗芳苷可降低小鼠气道炎症并缓解与过敏性哮喘相关的症状，其机制为减少氧化应激。体外研究表明，异罗芳苷以浓度依赖方式抑制 CYP3A4、2C9 和 2D6 酶活性。目前尚未记录该植物存在重大安全问题或药物相互作用，但仍需进一步研究，以充分了解其潜在益处与风险。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 肺损伤标志物减少和抗氧化活性增强，提示通过Nrf2信号通路在ALI中的保护作用。
- ISO治疗显示剂量依赖性地减少了梗死体积和神经功能缺损，并在大鼠脑缺血/再灌注后激活了PI3K/Akt途径。
- isoshraptonigin 减少了气道炎症和氧化应激，减轻了小鼠的过敏性哮喘症状。
- 异索黑根提取物抑制了体外的CYP3A4、2C9和2D6浓度依赖性地。
Frequently asked questions
What is Gnetum leptostachyum?
Gnetum leptostachyum (Gnetum leptostachyum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Gnetum leptostachyum?
4 sourced findings are recorded for Gnetum leptostachyum; the strongest carries evidence grade D. For example: 肺损伤标志物减少和抗氧化活性增强，提示通过Nrf2信号通路在ALI中的保护作用。
How strong is the evidence for Gnetum leptostachyum?
The strongest finding for Gnetum leptostachyum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Gnetum leptostachyum safe? What are the side effects?
No major safety issues are recorded for Gnetum leptostachyum in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Gnetum leptostachyum interact with medications?
No drug interactions are recorded for Gnetum leptostachyum in our sources. This does not rule them out — check with a pharmacist.
Is Gnetum leptostachyum a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Isorhapontigenin alleviates cerebral ischemia/reperfusion injuries in rats and modulated the PI3K/Akt signaling pathway. literature abstract metadata
- T2 Isorhapontigenin alleviates lipopolysaccharide-induced acute lung injury via modulating Nrf2 signaling. literature abstract metadata
- T2 In Vitro Inhibitory Effect of Isorhapontigenin on Cytochrome P450 Enzymes (CYP3A4, 2C9, and 2D6) and Its Characteristics. literature abstract metadata
- T2 Isorhapontigenin attenuates allergic asthma by reducing airway inflammation and oxidative stress. literature abstract metadata