Bitter Oleander
Holarrhena pubescens
Holarrhena pubescens, a plant traditionally used in Mayurbhanj, Odisha, has not been documented for specific traditional uses. Scientific studies have identified several steroidal alkaloids from this plant that exhibit in vitro antiprotozoal activity against Trypanosoma brucei rhodesiense and Plasmodium falciparum, suggesting potential anti-malarial properties. Additionally, the leaves extract biosynthesized copper nanoclusters demonstrated selective detection of bilirubin in biofluids and showed antimicrobial activity against Vancomycin-resistant Enterococcus (VRE), with synergistic effects when used alongside vancomycin and cefoxitin, as well as reduced biofilm formation. While no major safety issues or drug interactions have been recorded, the current evidence is limited and further research is needed to substantiate these findings comprehensively.
- 最佳证据
- A
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 霍拉伦纳（pubescens）树叶提取物生物合成的铜纳米簇在生物体液中显示出对胆红素的选择性检测。
- 该审查确定了40种用于马尔巴南（Mayurbhanj）、奥里萨邦（Odisha）疟疾治疗的植物物种。
- 研究从Holarrhena pubescens中鉴定出几种甾体生物碱，具有体外抗Trypanosoma brucei rhodesiense和Plasmodium falciparum活性。
- PBN 展示了对 VRE 的抗菌活性，与万古霉素和cephoxitin 显示协同作用，并减少了生物膜的形成。
Frequently asked questions
What is Bitter Oleander?
Bitter Oleander (Holarrhena pubescens) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bitter Oleander?
4 sourced findings are recorded for Bitter Oleander; the strongest carries evidence grade A. For example: 霍拉伦纳（pubescens）树叶提取物生物合成的铜纳米簇在生物体液中显示出对胆红素的选择性检测。
How strong is the evidence for Bitter Oleander?
The strongest finding for Bitter Oleander carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Bitter Oleander safe? What are the side effects?
No major safety issues are recorded for Bitter Oleander in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bitter Oleander interact with medications?
No drug interactions are recorded for Bitter Oleander in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bitter Oleander?
Bitter Oleander is also known as: ecorce de conessie.
Is Bitter Oleander a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Biosynthesis of copper nanoclusters for fluorescence detection of bilirubin in biofluids. literature abstract metadata
- T2 A review on the ethnomedicinal plants used for the traditional treatment of malaria in the Mayurbhanj district of Odisha, India. literature abstract metadata
- T2 Pubescine as a Novel Antibacterial Agent Against Vancomycin-Resistant Enterococcus: Growth Inhibition, Antibiotic Synergy, and Anti-Biofilm Activity. literature abstract metadata
- T2 Identification of Steroidal Alkaloids with In Vitro Antiprotozoal Activity from Holarrhena pubescens Wall. ex G. Don. literature abstract metadata