FolkKB

Paecilomyces hepiali

Paecilomyces hepiali

Paecilomyces hepiali 是一种已研究其潜在药用特性的真菌。虽然这种植物的传统用途未有详细记录，但研究表明它可能对肝脏健康和免疫系统具有应用价值。体外和体内研究显示，Paecilomyces hepiali Chen（Cs-4）的多糖可以通过抑制 TGF-β1/Smad 和 NLRP3/Caspase-1 途径来抑制 HSCs 活化从而减少肝纤维化的标志物，尽管这种证据的力量仍在评估中。此外，某些 Paecilomyces hepiali 的菌株，如 PH4477，可以将苯基乙酸分解为 2-羟基苯基乙酸和 4-羟基苯基乙酸，这可能具有代谢益处。Paecilomyces hepiali 的补充剂在改善免疫抑制小鼠的肠道微生物群组成并增强其免疫力方面显示出潜力，但需要进一步研究来确认这些发现。尚未记录该真菌的重大安全问题或已知药物相互作用。

速览
最佳证据
A
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • Paecilomyces hepiali PH4477 和其他真菌菌株高效降解苯乙酸，主要产生2-羟基苯乙酸和4-羟基苯乙酸作为代谢产物。 D PMID
  • Probiotic supplementation showed potential benefits in improving serum creatinine, insulin resistance, lipid profiles, and reducing inflammatory markers in diabetic kidney disease patients, but larger studies are needed. A PMID
  • Paecilomyces hepiali Chen（Cs-4）多糖通过抑制TGF-β1/Smad和NLRP3/Caspase-1途径减少了肝纤维化，在体内外模型中均有作用。 D PMID
  • 研究发现，Paecilomyces hepiali 的总抗氧化能力高于其他样品。 D PMID
  • 从猪胆中提取的FPH在环磷酰胺诱导的小鼠中调节免疫和肠道微生物群具有潜力，通过调节细胞因子分泌和紧密连接蛋白表达。 D PMID

Frequently asked questions

What is Paecilomyces hepiali?

Paecilomyces hepiali (Paecilomyces hepiali) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Paecilomyces hepiali?

5 sourced findings are recorded for Paecilomyces hepiali; the strongest carries evidence grade A. For example: Paecilomyces hepiali PH4477 和其他真菌菌株高效降解苯乙酸，主要产生2-羟基苯乙酸和4-羟基苯乙酸作为代谢产物。

How strong is the evidence for Paecilomyces hepiali?

The strongest finding for Paecilomyces hepiali carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Paecilomyces hepiali safe? What are the side effects?

No major safety issues are recorded for Paecilomyces hepiali in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Paecilomyces hepiali interact with medications?

No drug interactions are recorded for Paecilomyces hepiali in our sources. This does not rule them out — check with a pharmacist.

Is Paecilomyces hepiali a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Positive effects of extracellular polysaccharides from Paecilomyces hepiali on immune-enhancing properties by regulating gut microbiota in cyclophosphamide-induced mice. literature abstract metadata
  2. T2 Analysis of Metabolic Profiles and Antioxidant Activity of Chinese Cordyceps, Ophiocordyceps sinensis, and Paecilomyces hepiali Based on Untargeted Metabolomics. literature abstract metadata
  3. T2 Fungal degradation of phenylacetate focusing on CRISPR/Cas9-assisted characterization of two oxidative enzyme genes of Akanthomyces muscarius AM1091. literature abstract metadata
  4. T2 Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro. literature abstract metadata
  5. T2 Effects of probiotic supplementation on diabetic kidney disease: a systematic review and meta-analysis of randomized controlled trials. literature abstract metadata