FolkKB

Paecilomyces hepiali

Paecilomyces hepiali

Paecilomyces hepiali，一种真菌物种，传统上未被用于任何已知的医学实践。科学证据表明，某些 Paecilomyces hepiali 菌株能够降解苯乙酸酯，并可能在改善血清肌酐水平、胰岛素抵抗、脂质谱以及降低糖尿病肾病患者炎症标志物方面具有潜在益处；然而，需要更广泛的研究来确认这些发现。在另一项研究中，Paecilomyces hepiali Chen (Cs-4) 多糖被发现在体内外模型中通过抑制 TGF‑β1/Smad 和 NLRP3/Caspase‑1 通路来降低肝纤维化，提示可能具有肝脏保护作用。此外，Paecilomyces hepiali 的总抗氧化能力高于其他样本。尚未发现该真菌存在主要安全问题或记录的药物相互作用。

速览
最佳证据
A
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • Paecilomyces hepiali PH4477 和其他真菌菌株高效降解苯乙酸，主要产生2-羟基苯乙酸和4-羟基苯乙酸作为代谢产物。 D PMID
  • 益生菌补充剂在改善糖尿病肾病患者的血清肌酐、胰岛素抵抗、血脂水平和减少炎症标志物方面显示出潜在的益处，但需要更大规模的研究。 A PMID
  • Paecilomyces hepiali Chen（Cs-4）多糖通过抑制TGF-β1/Smad和NLRP3/Caspase-1途径减少了肝纤维化，在体内外模型中均有作用。 D PMID
  • 研究发现，Paecilomyces hepiali 的总抗氧化能力高于其他样品。 D PMID
  • 从猪胆中提取的FPH在环磷酰胺诱导的小鼠中调节免疫和肠道微生物群具有潜力，通过调节细胞因子分泌和紧密连接蛋白表达。 D PMID

Frequently asked questions

What is Paecilomyces hepiali?

Paecilomyces hepiali (Paecilomyces hepiali) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Paecilomyces hepiali?

5 sourced findings are recorded for Paecilomyces hepiali; the strongest carries evidence grade A. For example: Paecilomyces hepiali PH4477 和其他真菌菌株高效降解苯乙酸，主要产生2-羟基苯乙酸和4-羟基苯乙酸作为代谢产物。

How strong is the evidence for Paecilomyces hepiali?

The strongest finding for Paecilomyces hepiali carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Paecilomyces hepiali safe? What are the side effects?

No major safety issues are recorded for Paecilomyces hepiali in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Paecilomyces hepiali interact with medications?

No drug interactions are recorded for Paecilomyces hepiali in our sources. This does not rule them out — check with a pharmacist.

Is Paecilomyces hepiali a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Positive effects of extracellular polysaccharides from Paecilomyces hepiali on immune-enhancing properties by regulating gut microbiota in cyclophosphamide-induced mice. literature abstract metadata
  2. T2 Analysis of Metabolic Profiles and Antioxidant Activity of Chinese Cordyceps, Ophiocordyceps sinensis, and Paecilomyces hepiali Based on Untargeted Metabolomics. literature abstract metadata
  3. T2 Fungal degradation of phenylacetate focusing on CRISPR/Cas9-assisted characterization of two oxidative enzyme genes of Akanthomyces muscarius AM1091. literature abstract metadata
  4. T2 Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro. literature abstract metadata
  5. T2 Effects of probiotic supplementation on diabetic kidney disease: a systematic review and meta-analysis of randomized controlled trials. literature abstract metadata