FolkKB

Calabar bean

Physostigma venenosum

毒葛木（Physostigma venenosum），又称卡拉巴豆，源自西非的传统医学实践。传统上，其特定用途的使用记录并不广泛；然而，它的种子曾在当地仪式中被使用，并后来进行了科学研究。从这种植物中提取的毒扁豆碱显示出改善认知功能和减少帕金森病神经细胞α-突触核蛋白表达的潜力，尽管证据仍处于初步阶段。此外，某些提取物在体外表现出潜在的镇痛活性。该植物还导致了毒扁豆碱作为眼内降压剂的发展。虽然早期毒性研究记录了其使用和效果，包括地方仪式以及随后的科学研究，但尚未记录主要的安全问题或药物相互作用。然而，进一步的研究是必要的，以全面了解其应用和风险。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • 从毒蜜豆（Physostigma venenosum）中提取的吡斯地明在改善帕金森病神经细胞系的认知功能和减少α-突触核蛋白表达方面显示出潜力。 D PMID
  • 某些Physostigma venenosum提取物在体外受体结合试验中显示出潜在的镇痛活性。 D PMID
  • Physostigma venenosum 植物启发了拟毒蕈碱的开发，这是一种眼内降压剂。 D PMID
  • 研究记录了从Physostigma venenosum种子中提取的吡斯地明早期毒理学和效应，包括其在地方仪式中的使用以及随后的科学研究。 D PMID
  • 吡斯的明，来自毒葛豆（Physostigma venenosum）的一种生物碱，在治疗痴呆方面作为胆碱酯酶抑制剂显示出潜力。 D PMID

Frequently asked questions

What is Calabar bean?

Calabar bean (Physostigma venenosum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Calabar bean?

5 sourced findings are recorded for Calabar bean; the strongest carries evidence grade D. For example: 从毒蜜豆（Physostigma venenosum）中提取的吡斯地明在改善帕金森病神经细胞系的认知功能和减少α-突触核蛋白表达方面显示出潜力。

How strong is the evidence for Calabar bean?

The strongest finding for Calabar bean carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Calabar bean safe? What are the side effects?

No major safety issues are recorded for Calabar bean in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Calabar bean interact with medications?

No drug interactions are recorded for Calabar bean in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Calabar bean?

Calabar bean is also known as: Физостигма ядовитая, Fève de Calabar.

Is Calabar bean a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays. literature abstract metadata
  2. T2 The early toxicology of physostigmine: a tale of beans, great men and egos. literature abstract metadata
  3. T2 The role of phytochemicals in the treatment and prevention of dementia. literature abstract metadata
  4. T2 Nature as a source of drugs for ophthalmology. literature abstract metadata
  5. T2 A Review on Phytochemical Constituents used as Current Treatment Strategies for Neurodegenerative Disease. literature abstract metadata