FolkKB

Calabar bean

Physostigma venenosum

非洲薯蓣（Physostigma venenosum）是一种攀援植物，被广泛应用于各种传统疗法。传统上，它被用作阿托品和士的宁等物质的解毒剂，并用于治疗关节炎、风湿病、痉挛和重症肌无力等疾病。科学证据表明，从该植物中提取的非索替明可能有助于改善认知功能，并降低某些帕金森病神经细胞系中α-突触蛋白的表达。一些提取物在体外试验中也显示出潜在的镇痛活性，并且该植物为眼压降低药物的开发做出了贡献。目前尚未记录到重大的安全问题或显著的药物相互作用。

速览
传统用于
解毒剂 · 解毒剂（阿托品）
传统体系
传统
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

传统用途

科学怎么说

  • 从毒蜜豆（Physostigma venenosum）中提取的吡斯地明在改善帕金森病神经细胞系的认知功能和减少α-突触核蛋白表达方面显示出潜力。 D PMID
  • 某些Physostigma venenosum提取物在体外受体结合试验中显示出潜在的镇痛活性。 D PMID
  • Physostigma venenosum 植物启发了拟毒蕈碱的开发，这是一种眼内降压剂。 D PMID
  • 研究记录了从Physostigma venenosum种子中提取的吡斯地明早期毒理学和效应，包括其在地方仪式中的使用以及随后的科学研究。 D PMID
  • 吡斯的明，来自毒葛豆（Physostigma venenosum）的一种生物碱，在治疗痴呆方面作为胆碱酯酶抑制剂显示出潜力。 D PMID

Frequently asked questions

What is Calabar bean?

Calabar bean (Physostigma venenosum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What is Calabar bean traditionally used for?

Traditional sources record Calabar bean for: 解毒剂, 解毒剂（阿托品）, 解毒剂 (番木鳖碱), 关节炎, 滑囊炎, 纤维炎. This reflects traditional use, not a proven medical treatment.

Which traditions use Calabar bean?

Calabar bean appears in these traditions in our sources: traditional.

What does the scientific evidence say about Calabar bean?

5 sourced findings are recorded for Calabar bean; the strongest carries evidence grade D. For example: 从毒蜜豆（Physostigma venenosum）中提取的吡斯地明在改善帕金森病神经细胞系的认知功能和减少α-突触核蛋白表达方面显示出潜力。

How strong is the evidence for Calabar bean?

The strongest finding for Calabar bean carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Calabar bean safe? What are the side effects?

No major safety issues are recorded for Calabar bean in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Calabar bean interact with medications?

No drug interactions are recorded for Calabar bean in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Calabar bean?

Calabar bean is also known as: Физостигма ядовитая, Fève de Calabar.

Is Calabar bean a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T3 Dr. Duke's Ethnobotanical Database public domain (USDA ARS — attribute Dr. Duke's)
  2. T2 Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays. literature abstract metadata
  3. T2 The early toxicology of physostigmine: a tale of beans, great men and egos. literature abstract metadata
  4. T2 The role of phytochemicals in the treatment and prevention of dementia. literature abstract metadata
  5. T2 Nature as a source of drugs for ophthalmology. literature abstract metadata
  6. T2 A Review on Phytochemical Constituents used as Current Treatment Strategies for Neurodegenerative Disease. literature abstract metadata