Blister Bush
Plumbago zeylanica
印度铅丹（Plumbago zeylanica），又称印度铅草，是一种传统药物，在阿育吠陀和乌尼昂实践中被使用。它传统上用于治疗各种皮肤疾病和伤口，但具体的用途没有很好地记录下来。科学研究表明，在印度铅丹中发现的plumbagin化合物显示出对碳青霉烯耐药性Acinetobacter baumannii具有显著的抗菌活性，并且还表现出生物膜破坏作用，尽管这些发现尚未转化为临床应用。该研究还在酵母中成功重建了plumbagin的生物合成途径，确认了六个基因的功能并为可持续生产提供了平台。PZE（plumbagin锌复合物）显示出了剂量依赖性的抑制毒蛋白酶和胶原酶活性的效果，并且在体内保持了纤维蛋白原的完整性并且表现出保护作用而没有显著毒性。值得注意的是，在某些社区中，女性比男性对植物用途的知识更多。尚未记录该植物的重大安全问题或药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 该研究成功地在酵母中重建了没食子酸的生物合成途径，确认了六个基因的功能作用，并建立了可持续生产没食子酸的平台。
- 来自Plumbago zeylanica的没食子酸表现出对碳青霉烯耐药Acinetobacter baumannii显著的抗菌和生物膜破坏活性，但未测试任何临床剂量。
- PZE 展现了剂量依赖性对毒液蛋白酶和胶原酶活性的抑制作用，保持了纤维蛋白原的完整性，并在体内表现出保护作用而无显著毒性。
- The study documented 125 medicinal plants, with women showing greater knowledge of plant uses than men.
Frequently asked questions
What is Blister Bush?
Blister Bush (Plumbago zeylanica) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Blister Bush?
4 sourced findings are recorded for Blister Bush; the strongest carries evidence grade D. For example: 该研究成功地在酵母中重建了没食子酸的生物合成途径，确认了六个基因的功能作用，并建立了可持续生产没食子酸的平台。
How strong is the evidence for Blister Bush?
The strongest finding for Blister Bush carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Blister Bush safe? What are the side effects?
No major safety issues are recorded for Blister Bush in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Blister Bush interact with medications?
No drug interactions are recorded for Blister Bush in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Blister Bush?
Blister Bush is also known as: Plombago de Ceylan.
Is Blister Bush a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Ethnobotanical heritage and conservation priorities of medicinal flora in a remote Himalayan border region of Azad Kashmir, Pakistan. literature abstract metadata
- T2 De novo synthesis of plant polyketide plumbagin in yeast: a platform for sustainable production of naphthoquinones. literature abstract metadata
- T2 Plumbagin Disrupts Biofilm Integrity and Resistance Gene Expression in Carbapenem-Resistant Acinetobacter baumannii. literature abstract metadata
- T2 Ethnopharmacological evaluation of Plumbago zeylanica L. against Russell's viper envenomation: a combined computational and experimental study. literature abstract metadata