FolkKB

American Mandrake

Podophyllum peltatum

Podophyllum peltatum，常被称为Mayapple或Allegheny Chinkapin，是一种原产于北美东部的传统药用植物。它在美国土著和民间医学中用于多种疾病，但具体用途在文献中并未得到充分记录。科学研究主要聚焦其化学成分，尤其是podophyllotoxin，该物质显示出潜在的抗癌活性。研究表明，碳固定模式随季节变化而不同，从而影响植物的生长和资源配置。此外，目前正在探索使用装载有podophyllotoxin或杜松提取物的胶束进行靶向药物递送，以用于癌症治疗。基于酵母的途径成功建立了生产(-)-4'-desmethyl-epipodophyllotoxin（依托泊苷合成中的中间体）的过程。截至目前，尚未记录Podophyllum peltatum存在显著安全问题或已知药物相互作用。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • 研究发现，在生长季节不同时间固定的碳被以不同方式利用，且在Podophyllum peltatum中各个季节之间的再分配有限，这影响了其人口统计学。 D PMID
  • 研究评估了负载有podophyllotoxin或 juniper提取物的胶束作为潜在抗癌药物载体的用途。 D PMID
  • 这项研究建立了一种基于酵母的高效途径，用于生产(-)-4'-去甲基-乙基纤维素毒素，这是依托泊苷合成中的中间体。 D PMID
  • 研究成功克隆并分析了参与白花蛇舌草中podophyllotoxin生物合成的关键基因ShOMT3。 D PMID

Frequently asked questions

What is American Mandrake?

American Mandrake (Podophyllum peltatum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about American Mandrake?

4 sourced findings are recorded for American Mandrake; the strongest carries evidence grade D. For example: 研究发现，在生长季节不同时间固定的碳被以不同方式利用，且在Podophyllum peltatum中各个季节之间的再分配有限，这影响了其人口统计学。

How strong is the evidence for American Mandrake?

The strongest finding for American Mandrake carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is American Mandrake safe? What are the side effects?

No major safety issues are recorded for American Mandrake in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does American Mandrake interact with medications?

No drug interactions are recorded for American Mandrake in our sources. This does not rule them out — check with a pharmacist.

What are the common names of American Mandrake?

American Mandrake is also known as: Подофилл щитовидный, Podophylle pelté.

Is American Mandrake a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Polycarbonate-Based Copolymer Micelles as Biodegradable Carriers of Anticancer Podophyllotoxin or Juniper Extracts. literature abstract metadata
  2. T2 Interactions between developmental phenology, carbon movement, and storage constrain demography in the understory clonal herb Podophyllum peltatum L. literature abstract metadata
  3. T2 Cloning and bioinformatics analysis of key gene ShOMT3 of podophyllotoxin biosynthesis pathway in Sinopodophyllum hexandrum. literature abstract metadata
  4. T2 A yeast-based platform for etoposide production via yatein bioconversion. literature abstract metadata