FolkKB

Bloodroot

Sanguinaria canadensis

Sanguinaria canadensis，常被称为bloodroot，起源于北美，并拥有悠久的传统使用历史。虽然在传统医学中具体用途记录不多，但研究表明其活性成分之一——sanguinarine，可通过降低炎症、氧化应激和细胞损伤来改善顺铂诱导的急性肾损伤。此外，sanguinarine 对金黄色葡萄球菌具有抗菌作用，其机制涉及膜完整性和IGPD活性的影响。科学证据还显示，sanguinarine 能调节肺癌及结直肠癌细胞中的关键信号通路，尽管其确切机制尚未完全阐明。sanguinarine 的肠道吸收受 P‑gp 蛋白显著影响，并涉及多种转运机制。目前尚未记录到 Sanguinaria canadensis 存在重大安全问题或药物相互作用。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • 血根碱通过减轻炎症、氧化应激和细胞损伤，改善了小鼠顺铂诱导的急性肾损伤。 D PMID
  • 研究鉴定出来自11种传统药用植物（包括北美血根草）的多种植物成分，这些成分可以调节肺癌和结肠癌细胞中的关键信号通路。 D PMID
  • 血根碱表现出抗菌作用并干扰了金黄色葡萄球菌的生物膜形成，影响了膜完整性及IGPD活性。 D PMID
  • 研究发现，血根碱的肠道吸收显著受P-gp蛋白影响，并涉及多种转运机制。 D PMID

Frequently asked questions

What is Bloodroot?

Bloodroot (Sanguinaria canadensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Bloodroot?

4 sourced findings are recorded for Bloodroot; the strongest carries evidence grade D. For example: 血根碱通过减轻炎症、氧化应激和细胞损伤，改善了小鼠顺铂诱导的急性肾损伤。

How strong is the evidence for Bloodroot?

The strongest finding for Bloodroot carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Bloodroot safe? What are the side effects?

No major safety issues are recorded for Bloodroot in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Bloodroot interact with medications?

No drug interactions are recorded for Bloodroot in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Bloodroot?

Bloodroot is also known as: Sanguinaire du Canada.

Is Bloodroot a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ. literature abstract metadata
  2. T2 Targeting membrane integrity and imidazoleglycerol-phosphate dehydratase: Sanguinarine multifaceted approach against Staphylococcus aureus biofilms. literature abstract metadata
  3. T2 Interplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways. literature abstract metadata
  4. T2 Attenuation of cisplatin-induced acute kidney injury by sanguinarine: modulation of oxidative stress, inflammation, and cellular damage. literature abstract metadata