FolkKB

Bushweeds

Securinega

塞库宁加是一种在传统医学中记载不详的植物，其具体的文化和历史用途尚不清楚。科学研究通过合成发现了四种新的塞库宁加以碱性化合物，并揭示了它们的结构组成。已发现两种硫转移酶在将碱性化合物从新塞库宁烷转化为塞库宁烷的过程中起作用。实验室研究表明，一种塞库宁加衍生物可能通过激活p38 MAPK途径抑制胰腺癌细胞的增殖和侵袭，从而上调CHOP表达。另一种衍生物显示出强大的Keap1-Nrf2通路激活作用，在小胶质细胞中诱导抗氧化和细胞保护反应，表明潜在的神经保护效果。迄今为止尚未记录塞库宁加的重大安全问题或药物相互作用。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • 该研究通过合成发现了四种新的 Securinega 生物碱，并确定了它们的结构。 D PMID
  • 鉴定出两种硫基转移酶在将碱基骨架从新塞奎林烷重塑为塞奎林烷中发挥作用。 D PMID
  • SCR 抑制胰腺癌细胞的增殖和侵袭，通过激活 p38 MAPK 途径上调 CHOP 的表达。 D PMID
  • 一种具有两个迈克尔受体的塞库宁碱衍生物显示出对Keap1-Nrf2途径的强大激活作用，诱导微胶质细胞产生抗氧化和细胞保护反应。 D PMID

Frequently asked questions

What is Bushweeds?

Bushweeds (Securinega) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Bushweeds?

4 sourced findings are recorded for Bushweeds; the strongest carries evidence grade D. For example: 该研究通过合成发现了四种新的 Securinega 生物碱，并确定了它们的结构。

How strong is the evidence for Bushweeds?

The strongest finding for Bushweeds carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Bushweeds safe? What are the side effects?

No major safety issues are recorded for Bushweeds in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Bushweeds interact with medications?

No drug interactions are recorded for Bushweeds in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Bushweeds?

Bushweeds is also known as: Секуринега.

Is Bushweeds a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Chemically guided single-cell transcriptomics reveals sulfotransferase-mediated scaffold remodeling in securinine biosynthesis. literature abstract metadata
  2. T2 Allosecurinine Derivative with Two Michael Acceptors Activates Keap1-Nrf2 Pathway. literature abstract metadata
  3. T2 Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress. literature abstract metadata
  4. T2 Discovery and synthesis of flueggeacosines D-F and securingine J. literature abstract metadata