White Hellebore
Veratrum lobelianum
Veratrum lobelianum，这种植物传统上未在任何已知的医疗实践中使用，显示出进行科学研究的潜力。研究表明，在液氮中储存18年后，其种子的发芽率显著降低至仅14.81%。一项初步研究发现，从该植物提取物激活了C. elegans中的DNA损伤检查点反应通过ATM/ATR和CHK-1途径，这可能表明对生殖细胞发育的干扰。此外，有证据表明，Veratrum lobelianum中的jervine、protoveratrine A和protoveratrine B可能会通过抑制NaV1.5钠通道引起心脏毒性。根据LC-MS-MS检测患者样本中生物碱的存在，诊断了四例中毒病例。目前尚未发现该植物存在重大安全问题或已记录的药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 储存于液氮中长达18年的Veratrum lobelianum种子的发芽率显著下降至14.81%。
- Veratrum lobelianum 提取物被发现通过 ATM/ATR 和 CHK-1 路径在 C. elegans 中激活 DNA 损伤检查点反应，可能扰乱生殖细胞发育。
- 该研究开发了一种LC-MS-MS方法，用于测定四例Veratrum lobelianum中毒患者血浆和尿液中jervine和protoveratrine A的含量。
- 杰尔文、原儿茶酚A和原儿茶酚B对NaV1.5表现出亲和力，可能有助于心脏毒性。
Frequently asked questions
What is White Hellebore?
White Hellebore (Veratrum lobelianum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about White Hellebore?
4 sourced findings are recorded for White Hellebore; the strongest carries evidence grade D. For example: 储存于液氮中长达18年的Veratrum lobelianum种子的发芽率显著下降至14.81%。
How strong is the evidence for White Hellebore?
The strongest finding for White Hellebore carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is White Hellebore safe? What are the side effects?
No major safety issues are recorded for White Hellebore in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does White Hellebore interact with medications?
No drug interactions are recorded for White Hellebore in our sources. This does not rule them out — check with a pharmacist.
What are the common names of White Hellebore?
White Hellebore is also known as: Чемерица Лобеля, Vératre de Lobel.
Is White Hellebore a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Veratrum Alkaloid Determination in Four Cases of Veratrum Aqua Poisonings. literature abstract metadata
- T2 Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study. literature abstract metadata
- T2 Exploring the Impact of Onobrychis cornuta and Veratrum lobelianum Extracts on C. elegans: Implications for MAPK Modulation, Germline Development, and Antitumor Properties. literature abstract metadata
- T2 IPPRAS Cryobank for the Conservation of Orthodox Seeds of Rare, Endangered, Medicinal, and Ornamental Plant Species-Current Research. literature abstract metadata