White Hellebore
Veratrum lobelianum
Veratrum lobelianum 是一种传统上仅在少数已记录实践中使用的植物，主要分布于北美洲某些地区。虽然其传统用途并未广泛记载，但研究表明，该植物储存的种子随时间推移会显著降低发芽率。科学证据显示其可能具有生物活性，包括通过 ATM/ATR 和 CHK‑1 通路在 C. elegans 中激活 DNA 损伤检查点反应，可能破坏生殖系发育。此外，研究已开发出一种方法，用于测定中毒病例血浆和尿液中的 jervine 与 protoveratrin A，提示这些化合物因其对 NaV1.5 通道的亲和力而可能导致心脏毒性。值得注意的是，目前未记录该植物存在显著安全问题或药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 储存于液氮中长达18年的Veratrum lobelianum种子的发芽率显著下降至14.81%。
- Veratrum lobelianum 提取物被发现通过 ATM/ATR 和 CHK-1 路径在 C. elegans 中激活 DNA 损伤检查点反应，可能扰乱生殖细胞发育。
- 该研究开发了一种LC-MS-MS方法，用于测定四例Veratrum lobelianum中毒患者血浆和尿液中jervine和protoveratrine A的含量。
- 杰尔文、原儿茶酚A和原儿茶酚B对NaV1.5表现出亲和力，可能有助于心脏毒性。
Frequently asked questions
What is White Hellebore?
White Hellebore (Veratrum lobelianum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about White Hellebore?
4 sourced findings are recorded for White Hellebore; the strongest carries evidence grade D. For example: 储存于液氮中长达18年的Veratrum lobelianum种子的发芽率显著下降至14.81%。
How strong is the evidence for White Hellebore?
The strongest finding for White Hellebore carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is White Hellebore safe? What are the side effects?
No major safety issues are recorded for White Hellebore in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does White Hellebore interact with medications?
No drug interactions are recorded for White Hellebore in our sources. This does not rule them out — check with a pharmacist.
What are the common names of White Hellebore?
White Hellebore is also known as: Чемерица Лобеля, Vératre de Lobel.
Is White Hellebore a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Veratrum Alkaloid Determination in Four Cases of Veratrum Aqua Poisonings. literature abstract metadata
- T2 Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study. literature abstract metadata
- T2 Exploring the Impact of Onobrychis cornuta and Veratrum lobelianum Extracts on C. elegans: Implications for MAPK Modulation, Germline Development, and Antitumor Properties. literature abstract metadata
- T2 IPPRAS Cryobank for the Conservation of Orthodox Seeds of Rare, Endangered, Medicinal, and Ornamental Plant Species-Current Research. literature abstract metadata