Coccinia grandis
Coccinia grandis
Coccinia grandis, also known as African cucumber or bitter melon, is traditionally used in various folk medicine practices across Africa and Asia but lacks specific traditional uses documented for this plant. Scientific evidence suggests potential anti-inflammatory, antimicrobial, and antioxidant activities that may aid in managing atopic dermatitis symptoms; however, more human trials are needed to confirm these findings. Lupeol, identified from the leaves of Coccinia grandis, has shown antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae, with results comparable to standard antibiotics. Comprehensive research indicates that this plant exhibits various biological activities, though specific phytoconstituents and mechanisms are yet to be fully elucidated. In animal studies, Coccinia grandis leaf extract improved kidney function, reduced oxidative stress, and decreased pro-inflammatory cytokines in rats on a high-lipid diet. No major safety issues or drug interactions have been recorded for this plant.
- Beste Evidenz
- D
- Warnhinweise
- —
Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.
Was die Wissenschaft sagt
- Die Studie zeigt an, dass Coccinia grandis zusammen mit anderen Pflanzen potentielle anti-entzündliche, antimikrobielle und antioxidative Eigenschaften bei der Behandlung von Symptomen der atopischen Dermatitis aufweist, aber mehr klinische Versuche sind erforderlich.
- Die Studie zeigte, dass Lupeol aus den Blättern von Coccinia grandis eine antimikrobielle Aktivität gegen carbapenem-resistentes Klebsiella pneumoniae mit einer Inhibitio-Zone vergleichbar zur Standardantibiotika aufweist.
- Das Blattextrakt von Coccinia grandis verbesserte die Nierenfunktion, reduzierte den氧化剂压力，并减少了促炎细胞因子。
- Durchforscht wurden Untersuchungen gezeigt, dass Coccinia grandis verschiedene biologische Aktivitäten aufweist, aber spezifische Phytoconstituente und Mechanismen noch nicht vollständig identifiziert wurden.
Frequently asked questions
What is Coccinia grandis?
Coccinia grandis (Coccinia grandis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Coccinia grandis?
4 sourced findings are recorded for Coccinia grandis; the strongest carries evidence grade D. For example: Die Studie zeigt an, dass Coccinia grandis zusammen mit anderen Pflanzen potentielle anti-entzündliche, antimikrobielle und antioxidative Eigenschaften bei der Behandlung von Symptomen der atopischen Dermatitis aufweist, aber mehr klinische Versuche sind erforderlich.
How strong is the evidence for Coccinia grandis?
The strongest finding for Coccinia grandis carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Coccinia grandis safe? What are the side effects?
No major safety issues are recorded for Coccinia grandis in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Coccinia grandis interact with medications?
No drug interactions are recorded for Coccinia grandis in our sources. This does not rule them out — check with a pharmacist.
Is Coccinia grandis a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Quellen
- T2 The therapeutic role of Coccinia grandis in flavor-enhancing high-lipid diet-induced chronic kidney disease: a dual role of NF-kB and TGF-β/smad in renal fibrosis. literature abstract metadata
- T2 Ethnomedicinal Uses, Phytochemistry, Pharmacological Activity, Therapeutic Potentials, and Functional Foods of Coccinia grandis (L.) Voigt: An Updated Review. literature abstract metadata
- T2 Biological assessment of Coccinia grandis leaf and Lupeol against β-lactam resistant Klebsiella pneumoniae through integrated in-silico and in-vitro studies. literature abstract metadata
- T2 Phytotherapeutic Potential of Medicinal Plants for Atopic Dermatitis: Centella asiatica, Clinacanthus nutans, Senna alata, and Coccinia grandis. literature abstract metadata