Coccinia grandis
Coccinia grandis
Coccinia grandis, also known as African cucumber or bitter melon, is traditionally used in various folk medicine practices across Africa and Asia but lacks specific traditional uses documented for this plant. Scientific evidence suggests potential anti-inflammatory, antimicrobial, and antioxidant activities that may aid in managing atopic dermatitis symptoms; however, more human trials are needed to confirm these findings. Lupeol, identified from the leaves of Coccinia grandis, has shown antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae, with results comparable to standard antibiotics. Comprehensive research indicates that this plant exhibits various biological activities, though specific phytoconstituents and mechanisms are yet to be fully elucidated. In animal studies, Coccinia grandis leaf extract improved kidney function, reduced oxidative stress, and decreased pro-inflammatory cytokines in rats on a high-lipid diet. No major safety issues or drug interactions have been recorded for this plant.
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同,请查阅所引来源。
科学怎么说
- 研究发现,Coccinia grandis与其他植物一起显示出潜在的抗炎、抗菌和抗氧化活性以管理特应性皮炎症状,但需要更多的人体试验。
- 研究发现,来自柯克西亚大叶(Coccinia grandis)叶片的卢佩尔醇对碳青霉烯耐药肺炎克雷伯菌显示出与标准抗生素相当的抗菌活性,抑制圈大小相似。
- Coccinia grandis 叶提取物改善了高脂饮食大鼠的肾功能,降低了氧化应激并减少了促炎细胞因子。
- 全面的研究表明,Coccinia grandis 表现出多种生物活性,但具体的植物成分和机制尚未完全确定。
Frequently asked questions
What is Coccinia grandis?
Coccinia grandis (Coccinia grandis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Coccinia grandis?
4 sourced findings are recorded for Coccinia grandis; the strongest carries evidence grade D. For example: 研究发现,Coccinia grandis与其他植物一起显示出潜在的抗炎、抗菌和抗氧化活性以管理特应性皮炎症状,但需要更多的人体试验。
How strong is the evidence for Coccinia grandis?
The strongest finding for Coccinia grandis carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Coccinia grandis safe? What are the side effects?
No major safety issues are recorded for Coccinia grandis in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Coccinia grandis interact with medications?
No drug interactions are recorded for Coccinia grandis in our sources. This does not rule them out — check with a pharmacist.
Is Coccinia grandis a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 The therapeutic role of Coccinia grandis in flavor-enhancing high-lipid diet-induced chronic kidney disease: a dual role of NF-kB and TGF-β/smad in renal fibrosis. literature abstract metadata
- T2 Ethnomedicinal Uses, Phytochemistry, Pharmacological Activity, Therapeutic Potentials, and Functional Foods of Coccinia grandis (L.) Voigt: An Updated Review. literature abstract metadata
- T2 Biological assessment of Coccinia grandis leaf and Lupeol against β-lactam resistant Klebsiella pneumoniae through integrated in-silico and in-vitro studies. literature abstract metadata
- T2 Phytotherapeutic Potential of Medicinal Plants for Atopic Dermatitis: Centella asiatica, Clinacanthus nutans, Senna alata, and Coccinia grandis. literature abstract metadata