Bloodroot
Sanguinaria
Sanguinaria, commonly known as bloodroot, originates from North America and has a long-standing tradition in Native American herbal medicine. Traditionally, it was used for various purposes such as skin treatments and as an expectorant, though specific uses are not well-documented. Scientific evidence suggests that sanguinarine, a key component of Sanguinaria, may have potential therapeutic benefits. Studies indicate that sanguinarine can improve cisplatin-induced acute kidney injury in mice by reducing inflammation, oxidative stress, and cellular damage. Additionally, it has shown antimicrobial properties against Staphylococcus aureus, affecting membrane integrity and IGPD activity, as well as modulating key signaling pathways in lung and colorectal cancer cells. Safety findings are generally positive with no major issues recorded; however, the limited data precludes definitive conclusions. There are currently no reported drug interactions associated with Sanguinaria use.
- Beste Evidenz
- D
- Warnhinweise
- —
Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.
Was die Wissenschaft sagt
- Die Studie identifiziert mehrere Phytoconstituente aus elf traditionellen Heilpflanzen, darunter Sanguinaria canadensis, die potentielle antitumorenactive Eigenschaften durch das Modulieren von Schlüsselsignalwege in vitro zeigen.
- Sanguinarin verbesserte den akuten Nierenschaden durch Cisplatins-Verwendung bei Mäusen durch die Reduzierung von Entzündung, Oxidativem Stress und Zellschäden.
- Sanguinarin zeigte antimikrobielle Eigenschaften und Einfluss auf die Biofilmbildung bei Staphylococcus aureus durch Beeinflussung der Membranintegrität und der IGPD-Aktivität.
- Die Studie zeigte, dass die im Darm aufgenommene Sanguinarine erheblich durch P-gp-Proteine beeinflusst wird und mehrere Transportmechanismen umfasst.
Frequently asked questions
What is Bloodroot?
Bloodroot (Sanguinaria) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bloodroot?
4 sourced findings are recorded for Bloodroot; the strongest carries evidence grade D. For example: Die Studie identifiziert mehrere Phytoconstituente aus elf traditionellen Heilpflanzen, darunter Sanguinaria canadensis, die potentielle antitumorenactive Eigenschaften durch das Modulieren von Schlüsselsignalwege in vitro zeigen.
How strong is the evidence for Bloodroot?
The strongest finding for Bloodroot carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Bloodroot safe? What are the side effects?
No major safety issues are recorded for Bloodroot in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bloodroot interact with medications?
No drug interactions are recorded for Bloodroot in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bloodroot?
Bloodroot is also known as: Сангвинария.
Is Bloodroot a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Quellen
- T2 Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ. literature abstract metadata
- T2 Targeting membrane integrity and imidazoleglycerol-phosphate dehydratase: Sanguinarine multifaceted approach against Staphylococcus aureus biofilms. literature abstract metadata
- T2 Interplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways. literature abstract metadata
- T2 Attenuation of cisplatin-induced acute kidney injury by sanguinarine: modulation of oxidative stress, inflammation, and cellular damage. literature abstract metadata