Xylopia aethiopica

Xylopia aethiopica

Xylopia aethiopica, commonly known as African calabash or graviola, is a plant native to tropical regions of Africa and South America. Traditionally, its use has not been extensively documented in any specific medical traditions. Scientific evidence suggests that the ethyl acetate fraction from the root of Xylopia aethiopica exhibits strong cytotoxic activity against HCC-70 cells, while the hexane extract from its fruit demonstrates activity against MCF-7 cells. Additionally, NTD-O2, an exopolysaccharide-stabilized emulsion derived from this plant, has shown enhanced antibacterial activity against certain foodborne pathogens and displayed selective antionchocercal and moderate antitrypanosomal activities; however, it contains a compound with known toxicological risks. Hematological parameters were observed to show minor changes, particularly reducing platelet levels, but no significant effects on other tested parameters. No major safety issues or recorded drug interactions have been identified for Xylopia aethiopica thus far.

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Beste Evidenz
D
Warnhinweise

Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.

Was die Wissenschaft sagt

  • Xylopia aethiopica verursachte bei höheren Dosen an Ratten geringfügige Veränderungen der hämatologischen Parameter, insbesondere eine Senkung der Blutplättchenzahlen. D PMID
  • Die Ethylacetat-Fraktion der Wurzel von Xylopia aethiopica zeigte starke zytotoxische Aktivität gegenüber den HCC-70-Zellen, während das Hexanextrakt ihrer Früchte eine Aktivität gegenüber den MCF-7-Zellen aufwies. D PMID
  • NTD-O2 zeigte selektive Antionkocherz-Aktivität und moderat antitrypansomale Aktivität, aber enthielt ein Stoff mit bekannten toxikologischen Risiken. D PMID
  • Diese Studie zeigte an, dass emulsionen mit exopolysacchardie-stabilisierungen aus Xylopia aethiopica eine verstärkte antimikrobielle Aktivität gegenüber bestimmten Lebensmittelpathogenen aufweisen. D PMID

Frequently asked questions

What is Xylopia aethiopica?

Xylopia aethiopica (Xylopia aethiopica) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Xylopia aethiopica?

4 sourced findings are recorded for Xylopia aethiopica; the strongest carries evidence grade D. For example: Xylopia aethiopica verursachte bei höheren Dosen an Ratten geringfügige Veränderungen der hämatologischen Parameter, insbesondere eine Senkung der Blutplättchenzahlen.

How strong is the evidence for Xylopia aethiopica?

The strongest finding for Xylopia aethiopica carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Xylopia aethiopica safe? What are the side effects?

No major safety issues are recorded for Xylopia aethiopica in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Xylopia aethiopica interact with medications?

No drug interactions are recorded for Xylopia aethiopica in our sources. This does not rule them out — check with a pharmacist.

Is Xylopia aethiopica a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Quellen

  1. T2 Enhanced antibacterial potential of exopolysaccharide-stabilized spice oil emulsions against foodborne pathogens. literature abstract metadata
  2. T2 Evaluation of NTD-O2, a Ghanaian herbal medicine, for onchocerciasis and animal African trypanosomiasis. literature abstract metadata
  3. T2 Antiproliferative activity of Xylopia aethiopica extracts and molecular docking studies of their main phytochemicals. literature abstract metadata
  4. T2 Acute (14-Day) and Subchronic (90-Day) Toxicity Evaluation of the Dried Fruit Spice Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) in Male and Female Wistar Rats. literature abstract metadata