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Gymnocarpium dryopteris, commonly known as the wood fern or hedge fern, is a traditional plant found in temperate regions. Its use in any specific traditional medicine practices has not been documented. Scientific studies have shown that its spores exhibit reduced germination and gametophyte viability in saline environments, with no viable spores detected in marine sediments. Cuticular waxes on the fronds of this fern species were analyzed, revealing species-specific compositions and amounts, though specific findings related to Gymnocarpium dryopteris are limited. Seventy-seven volatile organic compounds were identified in various French ferns, including coumarin and aldehydes, which are also found in "fougère" scents used in perfumery, suggesting potential aromatic or chemical properties. Fungal biomass associated with bryophytes was generally higher than that of co-occurring vascular plants, indicating a possible ecological interaction but not specific to Gymnocarpium dryopteris. Safety concerns for this plant are minimal; no major issues have been recorded. There is also no reported evidence of drug interactions.

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