Artocarpus lacucha
Artocarpus lacucha
Artocarpus lacucha，又称印度核桃或印度桑葚，起源于东南亚和印度的传统医学实践。尽管其具体用途尚未详细记录，但研究表明，通过乙酸乙酯提取的Artocarpus lacucha树皮提取物通常无毒且没有观察到不良反应水平（NOAEL）为400 mg/kg/天，但它对HepG2细胞表现出显著的细胞毒性。该植物还显示出明显的α-葡萄糖苷酶抑制活性和强大的乙酰胆碱酯酶抑制作用，这表明其可能用于管理血糖水平和认知功能等。此外，通过索克赫特提取（AL-SOX）从Artocarpus lacucha树皮中获得的己烷提取物也表现出强烈的抗菌性能，并对某些细菌具有膜破坏效应。迄今为止，尚未报告该植物存在重大安全问题或药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 研究发现，Artocarpus lacucha 乙酸乙酯树皮提取物在体外未显示细胞毒性，在急性及亚急性毒理学研究中一般无毒性，NOAEL 值为 400 毫克/公斤/天。
- Artocarpus lacucha 在HepG2细胞中显示出高细胞毒性，CC50为63.96 μg/mL。
- Artocarpus lacucha 显示了一种化合物对α-葡萄糖苷酶有显著抑制活性，而另一种则表现出强大的乙酰胆碱酯酶抑制作用。
- 从Artocarpus lacucha树皮中通过索克赫特提取法（AL-SOX）获得的己烷提取物，对某些细菌显示出强大的抗菌活性和膜破坏作用。
Frequently asked questions
What is Artocarpus lacucha?
Artocarpus lacucha (Artocarpus lacucha) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Artocarpus lacucha?
4 sourced findings are recorded for Artocarpus lacucha; the strongest carries evidence grade D. For example: 研究发现，Artocarpus lacucha 乙酸乙酯树皮提取物在体外未显示细胞毒性，在急性及亚急性毒理学研究中一般无毒性，NOAEL 值为 400 毫克/公斤/天。
How strong is the evidence for Artocarpus lacucha?
The strongest finding for Artocarpus lacucha carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Artocarpus lacucha safe? What are the side effects?
No major safety issues are recorded for Artocarpus lacucha in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Artocarpus lacucha interact with medications?
No drug interactions are recorded for Artocarpus lacucha in our sources. This does not rule them out — check with a pharmacist.
Is Artocarpus lacucha a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Toxicological evaluation of Artocarpus lacucha ethyl acetate extract: in vitro and in vivo assessment. literature abstract metadata
- T2 Identification of specialized metabolites from Artocarpus lacucha as potent α-glucosidase and acetylcholinesterase inhibitors: enzyme kinetic, in vitro and in silico study. literature abstract metadata
- T2 Ethnobotany, Cytotoxicity and Color Stability of Karen Natural Colorants. literature abstract metadata
- T2 Membrane-disrupting antibacterial activity of Artocarpus lacucha bark extract: a mechanistic study through experimental and computational approaches. literature abstract metadata