Artocarpus lacucha
Artocarpus lacucha
Artocarpus lacucha, commonly known as Indian Walnut or Indian Mulberry, originates from traditional medicine practices in Southeast Asia and India. While its specific uses are not well-documented, studies have shown that ethyl acetate bark extract of Artocarpus lacucha is generally non-toxic with a no observable adverse effect level (NOAEL) of 400 mg/kg/day, but it exhibits significant cytotoxicity against HepG2 cells. The plant also demonstrates notable α-glucosidase inhibitory activity and potent acetylcholinesterase inhibition, suggesting potential for managing glucose levels and cognitive functions respectively. Additionally, the hexane extract from Artocarpus lacucha bark, specifically obtained through Soxhlet extraction (AL-SOX), has shown strong antibacterial properties with membrane-disrupting effects against certain bacteria. To date, no major safety concerns or drug interactions have been reported for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found that Artocarpus lacucha ethyl acetate bark extract showed no cytotoxicity in vitro and was generally non-toxic in acute and subacute toxicity studies, with a NOAEL of 400 mg/kg/day.
- Artocarpus lacucha showed high cytotoxicity with a CC50 of 63.96 μg/mL in HepG2 cells.
- Artocarpus lacucha showed significant α-glucosidase inhibitory activity with one compound, while another displayed potent acetylcholinesterase inhibition.
- The hexane extract from Artocarpus lacucha bark, specifically obtained through Soxhlet extraction (AL-SOX), showed potent antibacterial activity with membrane-disrupting effects against certain bacteria.
Frequently asked questions
What is Artocarpus lacucha?
Artocarpus lacucha (Artocarpus lacucha) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Artocarpus lacucha?
4 sourced findings are recorded for Artocarpus lacucha; the strongest carries evidence grade D. For example: The study found that Artocarpus lacucha ethyl acetate bark extract showed no cytotoxicity in vitro and was generally non-toxic in acute and subacute toxicity studies, with a NOAEL of 400 mg/kg/day.
How strong is the evidence for Artocarpus lacucha?
The strongest finding for Artocarpus lacucha carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Artocarpus lacucha safe? What are the side effects?
No major safety issues are recorded for Artocarpus lacucha in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Artocarpus lacucha interact with medications?
No drug interactions are recorded for Artocarpus lacucha in our sources. This does not rule them out — check with a pharmacist.
Is Artocarpus lacucha a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Toxicological evaluation of Artocarpus lacucha ethyl acetate extract: in vitro and in vivo assessment. literature abstract metadata
- T2 Identification of specialized metabolites from Artocarpus lacucha as potent α-glucosidase and acetylcholinesterase inhibitors: enzyme kinetic, in vitro and in silico study. literature abstract metadata
- T2 Ethnobotany, Cytotoxicity and Color Stability of Karen Natural Colorants. literature abstract metadata
- T2 Membrane-disrupting antibacterial activity of Artocarpus lacucha bark extract: a mechanistic study through experimental and computational approaches. literature abstract metadata