Callicarpa arborea
Callicarpa arborea
Callicarpa arborea，一种起源于亚洲、特别是印度和中国的传统草药植物，在任何特定的传统实践中尚未广泛记录其使用情况。科学研究显示了令人鼓舞的结果，表明从该植物中提取的callicarpoids A-C对乳腺癌（MCF-7）和结肠癌（HCT-116）细胞系具有显著的细胞毒性作用。此外，化合物3显示出作为NLRP3炎症小体激活抑制剂的强大潜力，IC50值为3.153 μM，而化合物1在减少GSDMD-NT产生、 caspase-1 激活和IL-1β分泌方面表现出希望。Callicarpa arborea叶片的甲醇提取物还在小鼠研究中显示出显著的镇痛和抗炎活性。迄今为止，尚未记录该植物的重大安全问题或药物相互作用，尽管进一步的研究对于完全了解其潜在应用和风险是必要的。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 从Callicarpa arborea中提取的化合物1显示出作为NLRP3炎体抑制剂的潜力，通过减少GSDMD-NT产生、抑制caspase-1激活和抑制IL-1β分泌。
- 来自Callicarpa arborea的化合物2和3对乳腺癌和结肠癌细胞显示出显著的细胞毒性作用，诱导凋亡。
- 来自Callicarpa arborea的复合物3显示出作为NLRP3炎体激活抑制剂的强大潜力，IC50值为3.153 μM。
- 紫珠叶的甲醇提取物在小鼠中显示出显著的镇痛和抗炎活性。
Frequently asked questions
What is Callicarpa arborea?
Callicarpa arborea (Callicarpa arborea) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Callicarpa arborea?
4 sourced findings are recorded for Callicarpa arborea; the strongest carries evidence grade D. For example: 从Callicarpa arborea中提取的化合物1显示出作为NLRP3炎体抑制剂的潜力，通过减少GSDMD-NT产生、抑制caspase-1激活和抑制IL-1β分泌。
How strong is the evidence for Callicarpa arborea?
The strongest finding for Callicarpa arborea carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Callicarpa arborea safe? What are the side effects?
No major safety issues are recorded for Callicarpa arborea in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Callicarpa arborea interact with medications?
No drug interactions are recorded for Callicarpa arborea in our sources. This does not rule them out — check with a pharmacist.
Is Callicarpa arborea a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Callicarpnoids A-C, structurally intriguing ent-Clerodane diterpenoid dimers with cytotoxicity against MCF-7 and HCT-116 cell lines from Callicarpa arborea Roxb. literature abstract metadata
- T2 Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea Roxb. leaves. literature abstract metadata
- T2 Two New Prostaglandin-Like Compounds from Callicarpa arborea Roxb and Their NLRP3 Inflammasome Activation Inhibitory Activity. literature abstract metadata
- T2 Three New Clerodane Diterpenoids and Their NLRP3 Inflammasome Activation Inhibitory Activity from Callicarpa arborea Roxb. literature abstract metadata