FolkKB

Glycosmis pentaphylla

Glycosmis pentaphylla

甘草木五叶（Glycosmis pentaphylla）是一种传统上在某些亚洲草药医学实践中使用的植物。尽管具体的传统用途没有很好地记录，但研究表明其潜在的治疗应用具有令人鼓舞的结果。科学数据显示KT32，从甘草木五叶中提取的一种生物碱，对某些癌细胞系表现出良好的细胞毒性作用，可能具有抗癌潜力。此外，甘草木五叶的甲醇提取物被发现可以减轻CCl4诱导的小鼠肝纤维化，通过恢复肝脏功能并调节炎症和氧化应激反应来缓解。此外，从该植物衍生的功能化硒纳米颗粒在类似模型中表现出剂量依赖性的肝脏功能改善和减少纤维化标志物。网络药理学研究确定了与潜在抗癌作用相关的八种关键生物碱，但需要进一步的研究来确认这些发现。 甘草木五叶的安全性数据显示没有重大问题；然而，长期安全性概况尚未完全建立。目前还没有关于该植物与药物相互作用的报告。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • KT32（10c），源自五叶甘草碱类化合物的组蛋白去乙酰化酶和拓扑异构酶IIα双重抑制剂，在某些癌细胞系中表现出良好的细胞毒性活性。 D PMID
  • 甲醇提取物Glycosmis pentaphylla减轻了CCl4诱导的小鼠肝纤维化，通过恢复肝脏功能并调节炎症和氧化应激反应。 D PMID
  • 甘草五叶藤功能化硒纳米颗粒在CCl4诱导的肝损伤小鼠中表现出剂量依赖性的肝脏功能改善和纤维化标志物减少。 D PMID
  • 该研究识别并量化了八种关键的甘草木五叶碱在Glycosmis pentaphylla中的含量，通过网络药理学将其与潜在的抗癌作用联系起来。 D PMID

Frequently asked questions

What is Glycosmis pentaphylla?

Glycosmis pentaphylla (Glycosmis pentaphylla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Glycosmis pentaphylla?

4 sourced findings are recorded for Glycosmis pentaphylla; the strongest carries evidence grade D. For example: KT32（10c），源自五叶甘草碱类化合物的组蛋白去乙酰化酶和拓扑异构酶IIα双重抑制剂，在某些癌细胞系中表现出良好的细胞毒性活性。

How strong is the evidence for Glycosmis pentaphylla?

The strongest finding for Glycosmis pentaphylla carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Glycosmis pentaphylla safe? What are the side effects?

No major safety issues are recorded for Glycosmis pentaphylla in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Glycosmis pentaphylla interact with medications?

No drug interactions are recorded for Glycosmis pentaphylla in our sources. This does not rule them out — check with a pharmacist.

Is Glycosmis pentaphylla a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Semisynthesis of Glycosmis pentaphylla Alkaloid Derivatives: Pyranoacridone-Hydroxamic Acid Cytotoxic Conjugates with HDAC and Topoisomerase II α Dual Inhibitory Activity. literature abstract metadata
  2. T2 Glycosmis pentaphylla mitigates CCl4-induced hepatic fibrosis in Swiss albino murine model through suppression of TGF-β/Smad2/3 signaling, oxidative stress and inflammatory responses: in-vivo and in-silico approach. literature abstract metadata
  3. T2 HPLC-PDA and LC-HRMS/MS-based quantitative and qualitative analysis of Glycosmis pentaphylla alkaloids, and investigation of their anticancer potential through network pharmacology. literature abstract metadata
  4. T2 Selenium Nanoparticles Functionalized with Glycosmis pentaphylla Extract Attenuate Hepatic Fibrosis Through Modulation of Oxidative Stress and Anti-Inflammatory Responses. literature abstract metadata