FolkKB

Glycosmis pentaphylla

Glycosmis pentaphylla

Glycosmis pentaphylla，这种植物在医学实践中传统上记录不多，在科学研究中却显示出前景。研究表明，它可能通过恢复肝功能和调节炎症及氧化应激反应来减轻肝脏纤维化。此外，网络药理学分析表明，通过识别八种关键的生物碱，其可能存在抗肿瘤活性的可能性，其中一种特定的生物碱（KT32）在某些癌细胞系中表现出良好的细胞毒性作用。此外，Glycosmis pentaphylla功能化的硒纳米颗粒在动物模型中显示出减少纤维化标志物和改善肝功能的潜力。目前尚无已知的重大安全问题或药物相互作用与这种植物相关。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • KT32（10c），源自五叶甘草碱类化合物的组蛋白去乙酰化酶和拓扑异构酶IIα双重抑制剂，在某些癌细胞系中表现出良好的细胞毒性活性。 D PMID
  • Glycosmis pentaphylla methanolic extract mitigated CCl4-induced hepatic fibrosis in mice by restoring liver function, modulating inflammatory and oxidative stress responses. D PMID
  • 甘草五叶藤功能化硒纳米颗粒在CCl4诱导的肝损伤小鼠中表现出剂量依赖性的肝脏功能改善和纤维化标志物减少。 D PMID
  • 该研究识别并量化了八种关键的甘草木五叶碱在Glycosmis pentaphylla中的含量，通过网络药理学将其与潜在的抗癌作用联系起来。 D PMID

Frequently asked questions

What is Glycosmis pentaphylla?

Glycosmis pentaphylla (Glycosmis pentaphylla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Glycosmis pentaphylla?

4 sourced findings are recorded for Glycosmis pentaphylla; the strongest carries evidence grade D. For example: KT32（10c），源自五叶甘草碱类化合物的组蛋白去乙酰化酶和拓扑异构酶IIα双重抑制剂，在某些癌细胞系中表现出良好的细胞毒性活性。

How strong is the evidence for Glycosmis pentaphylla?

The strongest finding for Glycosmis pentaphylla carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Glycosmis pentaphylla safe? What are the side effects?

No major safety issues are recorded for Glycosmis pentaphylla in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Glycosmis pentaphylla interact with medications?

No drug interactions are recorded for Glycosmis pentaphylla in our sources. This does not rule them out — check with a pharmacist.

Is Glycosmis pentaphylla a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Semisynthesis of Glycosmis pentaphylla Alkaloid Derivatives: Pyranoacridone-Hydroxamic Acid Cytotoxic Conjugates with HDAC and Topoisomerase II α Dual Inhibitory Activity. literature abstract metadata
  2. T2 Glycosmis pentaphylla mitigates CCl4-induced hepatic fibrosis in Swiss albino murine model through suppression of TGF-β/Smad2/3 signaling, oxidative stress and inflammatory responses: in-vivo and in-silico approach. literature abstract metadata
  3. T2 HPLC-PDA and LC-HRMS/MS-based quantitative and qualitative analysis of Glycosmis pentaphylla alkaloids, and investigation of their anticancer potential through network pharmacology. literature abstract metadata
  4. T2 Selenium Nanoparticles Functionalized with Glycosmis pentaphylla Extract Attenuate Hepatic Fibrosis Through Modulation of Oxidative Stress and Anti-Inflammatory Responses. literature abstract metadata