Glycosmis pentaphylla
Glycosmis pentaphylla
Glycosmis pentaphylla is a plant traditionally used in certain Asian herbal medicine practices. While specific traditional uses are not well-documented, studies have shown promising results for its potential therapeutic applications. Scientific evidence indicates that KT32, an alkaloid derived from Glycosmis pentaphylla, exhibits good cytotoxic activity against certain cancer cell lines, suggesting possible anticancer properties. Additionally, the methanolic extract of Glycosmis pentaphylla has been found to mitigate CCl4-induced hepatic fibrosis in mice by restoring liver function and modulating inflammatory and oxidative stress responses. Furthermore, functionalized selenium nanoparticles derived from this plant showed dose-dependent improvements in hepatic function and reduced fibrosis markers in a similar model. Network pharmacology studies have identified eight key alkaloids linked to potential anticancer effects, though more research is needed to confirm these findings. Safety data for Glycosmis pentaphylla shows no major issues recorded; however, comprehensive long-term safety profiles are not available. There are currently no reported drug interactions associated with this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- KT32 (10c), a dual HDAC and Topo II α inhibitor derived from Glycosmis pentaphylla alkaloids, showed good cytotoxic activity against certain cancer cell lines.
- Glycosmis pentaphylla methanolic extract mitigated CCl4-induced hepatic fibrosis in mice by restoring liver function, modulating inflammatory and oxidative stress responses.
- Glycosmis pentaphylla-functionalized selenium nanoparticles showed dose-dependent improvements in hepatic function and reduced fibrosis markers in mice with CCl4-induced liver damage.
- This study identified and quantified eight key alkaloids in Glycosmis pentaphylla, linking them to potential anticancer effects through network pharmacology.
Frequently asked questions
What is Glycosmis pentaphylla?
Glycosmis pentaphylla (Glycosmis pentaphylla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Glycosmis pentaphylla?
4 sourced findings are recorded for Glycosmis pentaphylla; the strongest carries evidence grade D. For example: KT32 (10c), a dual HDAC and Topo II α inhibitor derived from Glycosmis pentaphylla alkaloids, showed good cytotoxic activity against certain cancer cell lines.
How strong is the evidence for Glycosmis pentaphylla?
The strongest finding for Glycosmis pentaphylla carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Glycosmis pentaphylla safe? What are the side effects?
No major safety issues are recorded for Glycosmis pentaphylla in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Glycosmis pentaphylla interact with medications?
No drug interactions are recorded for Glycosmis pentaphylla in our sources. This does not rule them out — check with a pharmacist.
Is Glycosmis pentaphylla a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Semisynthesis of Glycosmis pentaphylla Alkaloid Derivatives: Pyranoacridone-Hydroxamic Acid Cytotoxic Conjugates with HDAC and Topoisomerase II α Dual Inhibitory Activity. literature abstract metadata
- T2 Glycosmis pentaphylla mitigates CCl4-induced hepatic fibrosis in Swiss albino murine model through suppression of TGF-β/Smad2/3 signaling, oxidative stress and inflammatory responses: in-vivo and in-silico approach. literature abstract metadata
- T2 HPLC-PDA and LC-HRMS/MS-based quantitative and qualitative analysis of Glycosmis pentaphylla alkaloids, and investigation of their anticancer potential through network pharmacology. literature abstract metadata
- T2 Selenium Nanoparticles Functionalized with Glycosmis pentaphylla Extract Attenuate Hepatic Fibrosis Through Modulation of Oxidative Stress and Anti-Inflammatory Responses. literature abstract metadata