FolkKB

Harrisonia perforata

Harrisonia perforata

Harrisonia perforata 是一种传统上在某些非洲草药疗法中使用的植物。尽管其具体的传统用途尚未广泛记录，但研究表明该植物中的化合物具有潜在的抗肿瘤和抗炎活性。名为3的成分增加了paclitaxel对HCT-15细胞的活性，而未改变ABC转运蛋白的表达，这可能表明在癌症治疗中有协同作用的可能性。此外，从 Harrisonia perforata 中提取的包括芦丁在内的化合物显示出抑制由 SARS-CoV-2 刺突蛋白刺激引起的肺部炎症的潜力，通过减少 NLRP3 促炎体和 MAPK 信号通路。从这种植物的茎中鉴定出了四种新的黄酮类化合物；然而，在体外未观察到显著的细胞毒性活性。包含 Harrisonia perforata 的组合疗法在测试的组合中显示出高抗过敏、抗炎和抗菌活性。迄今为止，尚未报告 Harrisonia perforata 有任何重大安全问题或记录的药物相互作用。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • 来自Harrisonia perforata的复合物3增强了对HCT-15细胞的紫杉醇活性，而未改变ABC转运体的表达。 D PMID
  • 来自哈里森尼亚穿孔树的HPEE和黄酮醇抑制了由SARS-CoV-2刺突蛋白刺激引起的肺部炎症，通过减少NLRP3炎性小体和MAPK信号传导。 D PMID
  • 从Harrisonia perforata茎中鉴定出了四种新的黄酮类化合物，但未观察到显著的体外细胞毒性活性。 D PMID
  • HMB-123，由Ha-rak疗法、Piper betle和Garcinia mangostana组成的组合，在测试的组合中显示出最高的抗过敏、抗炎和抗菌活性。 D PMID

Frequently asked questions

What is Harrisonia perforata?

Harrisonia perforata (Harrisonia perforata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Harrisonia perforata?

4 sourced findings are recorded for Harrisonia perforata; the strongest carries evidence grade D. For example: 来自Harrisonia perforata的复合物3增强了对HCT-15细胞的紫杉醇活性，而未改变ABC转运体的表达。

How strong is the evidence for Harrisonia perforata?

The strongest finding for Harrisonia perforata carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Harrisonia perforata safe? What are the side effects?

No major safety issues are recorded for Harrisonia perforata in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Harrisonia perforata interact with medications?

No drug interactions are recorded for Harrisonia perforata in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Harrisonia perforata?

Harrisonia perforata is also known as: Гаррисония продырявленная.

Is Harrisonia perforata a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Chromones from stems of Harrisonia perforata. literature abstract metadata
  2. T2 In vitro biological activities of a combination of Ha-rak remedy, Piper betle, and Garcinia mangostana for the treatment of atopic dermatitis. literature abstract metadata
  3. T2 Luteolin-Rich Extract from Harrisonia perforata (Blanco) Merr. Root Alleviates SARS-CoV-2 Spike Protein-Stimulated Lung Inflammation via Inhibition of MAPK/NLRP3 Inflammasome Signaling Pathways. literature abstract metadata
  4. T2 Harperoids A-F, Complex Polyprenylated Acylphloroglucinols from Harrisonia perforata that Reverse Multidrug Resistance by Targeting ABC Transporter Function. literature abstract metadata