Harrisonia perforata
Harrisonia perforata
Harrisonia perforata is a plant traditionally used in certain African herbal medicine practices. While its specific traditional uses have not been extensively documented, studies have shown that compounds from this plant exhibit potential anti-cancer and anti-inflammatory activities. A compound named 3 increased the activity of paclitaxel against HCT-15 cells without altering ABC transporter expression, suggesting possible synergistic effects in cancer treatment. Additionally, extracts from Harrisonia perforata, including luteolin, have shown promise in inhibiting SARS-CoV-2 spike protein-stimulated lung inflammation by reducing NLRP3 inflammasome and MAPK signaling pathways. Four new chromones were identified from the stems of this plant; however, no significant in vitro cytotoxic activity was observed. A combination remedy including Harrisonia perforata showed high anti-allergic, anti-inflammatory, and antimicrobial activities among tested combinations. No major safety issues or recorded drug interactions have been noted for Harrisonia perforata to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Compound 3 from Harrisonia perforata increased paclitaxel activity against HCT-15 cells without altering ABC transporter expression.
- HPEE and luteolin from Harrisonia perforata inhibited SARS-CoV-2 spike protein-stimulated lung inflammation by reducing NLRP3 inflammasome and MAPK signaling.
- Four new chromones were identified from Harrisonia perforata stems, but no significant in vitro cytotoxic activity was observed.
- HMB-123, a combination of Ha-rak remedy, Piper betle, and Garcinia mangostana, showed the highest anti-allergic, anti-inflammatory, and antimicrobial activities among tested combinations.
Frequently asked questions
What is Harrisonia perforata?
Harrisonia perforata (Harrisonia perforata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Harrisonia perforata?
4 sourced findings are recorded for Harrisonia perforata; the strongest carries evidence grade D. For example: Compound 3 from Harrisonia perforata increased paclitaxel activity against HCT-15 cells without altering ABC transporter expression.
How strong is the evidence for Harrisonia perforata?
The strongest finding for Harrisonia perforata carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Harrisonia perforata safe? What are the side effects?
No major safety issues are recorded for Harrisonia perforata in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Harrisonia perforata interact with medications?
No drug interactions are recorded for Harrisonia perforata in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Harrisonia perforata?
Harrisonia perforata is also known as: Гаррисония продырявленная.
Is Harrisonia perforata a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Chromones from stems of Harrisonia perforata. literature abstract metadata
- T2 In vitro biological activities of a combination of Ha-rak remedy, Piper betle, and Garcinia mangostana for the treatment of atopic dermatitis. literature abstract metadata
- T2 Luteolin-Rich Extract from Harrisonia perforata (Blanco) Merr. Root Alleviates SARS-CoV-2 Spike Protein-Stimulated Lung Inflammation via Inhibition of MAPK/NLRP3 Inflammasome Signaling Pathways. literature abstract metadata
- T2 Harperoids A-F, Complex Polyprenylated Acylphloroglucinols from Harrisonia perforata that Reverse Multidrug Resistance by Targeting ABC Transporter Function. literature abstract metadata