FolkKB

Manchineel

Hippomane mancinella

Hippomane mancinella，通常称为马钦内尔树，在美洲的热带和亚热带地区生长。尽管其在传统医学中的使用尚未广泛记录，但已知它具有毒性，这导致了关于其危险性的警告故事和警告。科学研究表明种子具有潜在的抗疟疾活性，并且体外细胞毒性较低，暗示可能有医疗应用潜力。然而，某些飞虫种类如Anastrepha acris和A. ludens对果实进行解毒的机制表明直接人类食用可能是危险的。一份病例报告描述了接触该树后引起的接触性皮炎，在六周内完全恢复。该植物在果肉中含有一种名为18种酚类化合物，但缺乏Hippomanin A，这种物质被飞虫幼虫和成虫代谢。没有记录到重大安全问题或药物相互作用，但由于其毒性，直接食用果实仍然强烈不建议。

速览
最佳证据
D
注意事项
—

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

科学怎么说

  • Hippomane mancinella 种子显示出有希望的抗疟疾活性且细胞毒性较低。 D PMID
  • 研究发现，安斯特拉法 acris 和 A. ludens 的解毒机制相似，但 acris 具有专门的结构抗性，使其能够食用有毒的 Hippomane mancinella 果实。 D PMID
  • 该研究描述了马森尼尔树引起的刺激性接触性皮炎案例。 D PMID
  • 研究在海蓬子曼尼拉果肉中鉴定出了18种酚类化合物，但在幼虫和成虫中未检测到Hippomanin A的存在，表明A. acris可以代谢这种毒素。 D PMID
  • 食用马尼拉果通常会引起轻度症状，如腹痛和咽喉刺激，偶尔会出现更严重的并发症。 D PMID

Frequently asked questions

What is Manchineel?

Manchineel (Hippomane mancinella) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Manchineel?

5 sourced findings are recorded for Manchineel; the strongest carries evidence grade D. For example: Hippomane mancinella 种子显示出有希望的抗疟疾活性且细胞毒性较低。

How strong is the evidence for Manchineel?

The strongest finding for Manchineel carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Manchineel safe? What are the side effects?

No major safety issues are recorded for Manchineel in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Manchineel interact with medications?

No drug interactions are recorded for Manchineel in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Manchineel?

Manchineel is also known as: Манцинелловое дерево, Mancenillier.

Is Manchineel a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Severity of manchineel fruit (Hippomane mancinella) poisoning: A retrospective case series of 97 patients from French Poison Control Centers. literature abstract metadata
  2. T2 Insights into the Interaction between the Monophagous Tephritid Fly Anastrepha acris and its Highly Toxic Host Hippomane mancinella (Euphorbiaceae). literature abstract metadata
  3. T2 In vitro antiplasmodial activity of selected plants from the Colombian North Coast with low cytotoxicity. literature abstract metadata
  4. T2 Insights into the differences related to the resistance mechanisms to the highly toxic fruit Hippomane mancinella (Malpighiales: Euphorbiaceae) between the larvae of the sister species Anastrepha acris and Anastrepha ludens (Diptera: Tephri literature abstract metadata
  5. T2 Beware the Manchineel: A Case of Irritant Contact Dermatitis. literature abstract metadata