Purple Gromwell
Lithospermum erythrorhizon
紫草根（Lithospermum erythrorhizon），又称Zicao或紫草，是一种传统中药。传统上，在记录的实践中它并不广泛用于治疗特定疾病。科学研究表明，植物中的黄酮类化合物紫草素显示出抗炎和抗癌作用；然而，由于潜在毒性问题，临床应用受到限制。在过敏性皮炎动物模型中，紫草根治疗显著减轻了病情严重程度和搔抓行为，但未能完全恢复表皮屏障功能。荟萃分析表明，在实验性类风湿关节炎（RA）模型中，紫草素可以减少足肿胀和关节炎评分。安全记录显示没有重大问题被记录，并且目前尚未发现与该植物相关的药物相互作用。
- 最佳证据
- A
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 研究发现，经过基因编辑的LePPO1毛根，一种多酚氧化酶基因，显示shikonin含量降低而其他代谢物未受影响。
- 紫草素通过多种机制表现出抗炎和抗癌作用，但其临床应用受限于潜在毒性。
- 元分析表明，紫草素在实验性RA模型中显著减少了足垫水肿和关节炎评分。
- Zicao treatment significantly decreased dermatitis severity and scratching behavior in animal models of atopic dermatitis, but had limited effects on epidermal barrier restoration.
Frequently asked questions
What is Purple Gromwell?
Purple Gromwell (Lithospermum erythrorhizon) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Purple Gromwell?
4 sourced findings are recorded for Purple Gromwell; the strongest carries evidence grade A. For example: 研究发现，经过基因编辑的LePPO1毛根，一种多酚氧化酶基因，显示shikonin含量降低而其他代谢物未受影响。
How strong is the evidence for Purple Gromwell?
The strongest finding for Purple Gromwell carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Purple Gromwell safe? What are the side effects?
No major safety issues are recorded for Purple Gromwell in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Purple Gromwell interact with medications?
No drug interactions are recorded for Purple Gromwell in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Purple Gromwell?
Purple Gromwell is also known as: vorobejnik krasnokornevoj.
Is Purple Gromwell a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 A meta-analysis of the traditional herb Zicao and its active components for atopic dermatitis. literature abstract metadata
- T2 Shikonin: Unraveling its Multi-Mechanistic Anticancer and Anti- Inflammatory Mechanisms. literature abstract metadata
- T2 Immunopharmacological effects of shikonin in experimental rheumatoid arthritis: a systematic review and meta-analysis of in vivo studies. literature abstract metadata
- T2 CRISPR/Cas9-mediated genome editing reveals the involvement of a polyphenol oxidase in the shikonin-specific biosynthesis in Lithospermum erythrorhizon. literature abstract metadata