Milkthistle
Silybum
丝裂草（又称玛丽刺或牛奶刺）是一种传统药用植物，其根源可追溯至古代希腊和罗马。传统上，它被用于支持肝脏健康和解毒，在各种文化中都有使用，但具体用途差异很大。科学研究表明，丝裂草中的活性成分——丝兰素可能通过减少黄曲霉素残留并改善鱼类暴露于黄曲霉素和细菌感染后的免疫参数来对肝脏健康产生积极影响。此外，富含异丝裂素A的提取物显示出恢复对真菌药物耐药念珠菌种敏感性的前景，并表现出对抗前列腺癌潜在的抗肿瘤活性；然而，需要更多的随机临床试验以得出明确结论。安全资料表明没有重大问题被记录下来，目前也没有报告与使用丝裂草相关的药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 富含异鼠李素A的接骨木提取物与氟康唑联合使用，恢复了对唑类耐药的念珠菌属物种以及出现的多药耐药酵母分离株的唑类敏感性。
- 从刺芒柄花中提取的化合物在体外和体内对前列腺癌显示出有希望的抗肿瘤活性，但需要进一步随机试验。
- 三叶草素及其分离的黄酮醇木脂素拮抗肝X受体，显示出潜在的抗脂肪变性作用于肝细胞。
- 唾液酸补充减少了尼罗河鲈鱼因黄曲霉毒素中毒和细菌感染而引起的黄曲霉毒素残留，并改善了其免疫参数。
Frequently asked questions
What is Milkthistle?
Milkthistle (Silybum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Milkthistle?
4 sourced findings are recorded for Milkthistle; the strongest carries evidence grade D. For example: 富含异鼠李素A的接骨木提取物与氟康唑联合使用，恢复了对唑类耐药的念珠菌属物种以及出现的多药耐药酵母分离株的唑类敏感性。
How strong is the evidence for Milkthistle?
The strongest finding for Milkthistle carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Milkthistle safe? What are the side effects?
No major safety issues are recorded for Milkthistle in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Milkthistle interact with medications?
No drug interactions are recorded for Milkthistle in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Milkthistle?
Milkthistle is also known as: Расторопша, Chardon-Marie.
Is Milkthistle a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Silybum marianum-Derived Compounds in Prostate Cancer: Mechanisms of Action and Translational Potential. literature abstract metadata
- T2 In silico identification of isosilybin a targeting squalene epoxidase as an antifungal adjuvant with in vitro validation against azole-resistant Candida and emerging yeasts. literature abstract metadata
- T2 Silymarin conserves the efficacy of quinolone and sulfonamide in Nile tilapia (Oreochromis niloticus) subjected to aflatoxicosis and Streptococcus agalactiae infection. literature abstract metadata
- T2 Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists. literature abstract metadata