Milkthistle
Silybum
西利宾，又称玛丽刺芒柄花或奶蓟草，起源于地中海等地区的传统医学实践。传统上，它并未广泛用于特定的医疗用途，尽管其在民间疗法和草药中的使用是值得注意的。 科学证据表明，西利宾提取物，特别是富含异水飞蓟素A，与氟康唑联合使用对抗对唑类耐药的念珠菌可能具有潜在益处。此外，从植物中衍生出的化合物显示出体外和体内前列腺癌的有希望的抗肿瘤活性；然而，需要随机临床试验来确认这些结果。西利木宾，存在于西利宾中的黄酮醇木脂素混合物，通过拮抗肝X受体显示了潜在的抗脂肪变性作用，这可能对肝脏健康有益。此外，在尼罗河鲈鱼中观察到补充剂（西利木宾的一种成分）减少了黄曲霉素残留并改善了免疫参数。 根据当前数据，安全问题很小；没有记录重大问题。同样，没有关于西利宾与药物之间显著相互作用的报告。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 富含异鼠李素A的接骨木提取物与氟康唑联合使用，恢复了对唑类耐药的念珠菌属物种以及出现的多药耐药酵母分离株的唑类敏感性。
- 从刺芒柄花中提取的化合物在体外和体内对前列腺癌显示出有希望的抗肿瘤活性，但需要进一步随机试验。
- 三叶草素及其分离的黄酮醇木脂素拮抗肝X受体，显示出潜在的抗脂肪变性作用于肝细胞。
- 唾液酸补充减少了尼罗河鲈鱼因黄曲霉毒素中毒和细菌感染而引起的黄曲霉毒素残留，并改善了其免疫参数。
Frequently asked questions
What is Milkthistle?
Milkthistle (Silybum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Milkthistle?
4 sourced findings are recorded for Milkthistle; the strongest carries evidence grade D. For example: 富含异鼠李素A的接骨木提取物与氟康唑联合使用，恢复了对唑类耐药的念珠菌属物种以及出现的多药耐药酵母分离株的唑类敏感性。
How strong is the evidence for Milkthistle?
The strongest finding for Milkthistle carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Milkthistle safe? What are the side effects?
No major safety issues are recorded for Milkthistle in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Milkthistle interact with medications?
No drug interactions are recorded for Milkthistle in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Milkthistle?
Milkthistle is also known as: Расторопша, Chardon-Marie.
Is Milkthistle a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Silybum marianum-Derived Compounds in Prostate Cancer: Mechanisms of Action and Translational Potential. literature abstract metadata
- T2 In silico identification of isosilybin a targeting squalene epoxidase as an antifungal adjuvant with in vitro validation against azole-resistant Candida and emerging yeasts. literature abstract metadata
- T2 Silymarin conserves the efficacy of quinolone and sulfonamide in Nile tilapia (Oreochromis niloticus) subjected to aflatoxicosis and Streptococcus agalactiae infection. literature abstract metadata
- T2 Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists. literature abstract metadata