milk thistle

Silybum marianum

Silybum marianum, commonly known as milk thistle, is a traditional medicinal plant used in various cultures for centuries. It has been traditionally employed to support liver health and detoxification processes, although specific uses vary across different traditions. Scientific evidence suggests that silymarin, the active compound derived from Silybum marianum, may offer hepatoprotective effects by antagonizing liver X receptors. Additionally, there is promising in vitro and in vivo research indicating potential antineoplastic activity against prostate cancer, though more randomized trials are needed to confirm these findings. Notably, an enriched extract of Isosilybin A, when combined with fluconazole, has shown the ability to restore azole susceptibility in resistant Candida species. In contaminated fish studies, supplementation with sil (likely referring to silymarin) demonstrated some improvements in gene expression and immunity parameters compared to controls. No major safety issues or drug interactions have been recorded for Silybum marianum, though further research is ongoing to fully understand its potential benefits and applications.

速览
最佳证据
D
注意事项

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同,请查阅所引来源。

科学怎么说

  • 三叶草素及其分离的黄酮醇木脂素拮抗肝X受体,显示出潜在的抗脂肪变性作用于HepG2细胞中。 D PMID
  • 从绵马贯众中提取的化合物在体外和体内前列腺癌模型中显示出有希望的抗肿瘤活性,但需要进一步的随机试验。 D PMID
  • 富含异甘草素A的月见草提取物与氟康唑联合使用,恢复了对唑类耐药的念珠菌种和新兴酵母的唑类敏感性。 D PMID
  • 唾液酸补充降低了尼罗河鲈鱼因黄曲霉毒素中毒和细菌感染而引起的黄曲霉毒素残留,并改善了免疫参数。 D PMID

Frequently asked questions

What is milk thistle?

milk thistle (Silybum marianum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about milk thistle?

4 sourced findings are recorded for milk thistle; the strongest carries evidence grade D. For example: 三叶草素及其分离的黄酮醇木脂素拮抗肝X受体,显示出潜在的抗脂肪变性作用于HepG2细胞中。

How strong is the evidence for milk thistle?

The strongest finding for milk thistle carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is milk thistle safe? What are the side effects?

No major safety issues are recorded for milk thistle in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does milk thistle interact with medications?

No drug interactions are recorded for milk thistle in our sources. This does not rule them out — check with a pharmacist.

What are the common names of milk thistle?

milk thistle is also known as: расторопша, Chardon-Marie.

Is milk thistle a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Silybum marianum-Derived Compounds in Prostate Cancer: Mechanisms of Action and Translational Potential. literature abstract metadata
  2. T2 In silico identification of isosilybin a targeting squalene epoxidase as an antifungal adjuvant with in vitro validation against azole-resistant Candida and emerging yeasts. literature abstract metadata
  3. T2 Silymarin conserves the efficacy of quinolone and sulfonamide in Nile tilapia (Oreochromis niloticus) subjected to aflatoxicosis and Streptococcus agalactiae infection. literature abstract metadata
  4. T2 Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists. literature abstract metadata