Indian Ginseng
Withania somnifera
Withania somnifera，通常被称为阿什旺达（Ashwagandha），是一种传统上用于阿育吠陀医学的适应原植物。它已使用数百年来支持整体健康并管理压力。科学证据表明，从该植物提取的 Withaferin A 化合物通过涉及氧化还原稳态、自噬和凋亡机制，显示出潜在的抗乳腺癌活性；然而，由于口服生物利用度和模型异质性的挑战，还需要进一步研究。在临床试验中，阿什旺达已被证明可降低焦虑和压力标志物、降低皮质醇水平及甘油三酯，而在患有既往高血压的患者中未报告严重不良事件。高剂量根部提取物（2000 mg/天）在健康成年人12周内耐受良好。目前尚未记录主要安全问题或显著药物相互作用。
- 最佳证据
- A
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 从印度冬麻（Withania somnifera）中提取的阿魏酸A表现出多靶点抗乳腺癌活性，通过调节氧化还原稳态、自噬和凋亡。但由于口服生物利用度有限以及模型异质性，翻译面临挑战。
- 研究发现，无论是传统方法还是PCSЛ萃取方法都能从印度冬青Withania somnifera中提取出可测量的withaferin A含量，尽管NMR已被确认为可靠的定量分析方法。
- 印度紫檀显著降低了焦虑和应激标志物，降低了皮质醇水平和甘油三酯水平，在已有高血压的患者中没有出现严重不良事件。
- 高剂量的印度冬青根提取物（每日2000毫克）在健康成人中耐受良好，并且在12周内表现出良好的安全性特征。
- 一些临床前和临床证据表明，Withania somnifera 可能具有认知支持和神经保护的潜力，尽管仍需要更多标准化研究。
- 用蒸馏水提取的印度何首乌根和 withanolide A 在斑马鱼幼体中表现出类似地西泮的抗焦虑活性。
- 补气合甘草补充剂显著改善了成年人的认知功能（记忆、注意力、处理速度和执行功能）以及肌肉力量，但对体重或体脂百分比没有影响。
Frequently asked questions
What is Indian Ginseng?
Indian Ginseng (Withania somnifera) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Indian Ginseng?
7 sourced findings are recorded for Indian Ginseng; the strongest carries evidence grade A. For example: 从印度冬麻（Withania somnifera）中提取的阿魏酸A表现出多靶点抗乳腺癌活性，通过调节氧化还原稳态、自噬和凋亡。但由于口服生物利用度有限以及模型异质性，翻译面临挑战。
How strong is the evidence for Indian Ginseng?
The strongest finding for Indian Ginseng carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Indian Ginseng safe? What are the side effects?
No major safety issues are recorded for Indian Ginseng in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Indian Ginseng interact with medications?
No drug interactions are recorded for Indian Ginseng in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Indian Ginseng?
Indian Ginseng is also known as: Ti poc-poc.
Is Indian Ginseng a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Safety and efficacy of ashwagen (a standardized withania somnifera extract) in stress and anxiety with hypertension and associated cardiometabolic risk factors: a randomized, placebo-controlled trial. literature abstract metadata
- T2 Effects of Withania somnifera (L.) Dunal (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis. literature abstract metadata
- T2 Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods. literature abstract metadata
- T2 Safety and tolerability of Ashwagandha (Withania somnifera) root extract in healthy adults: a prospective, non-comparative study. literature abstract metadata
- T2 Withaferin A in breast cancer therapy: multi-targeted modulation of redox homeostasis, autophagy, and apoptosis. literature abstract metadata
- T2 Herbal Neurotherapeutics for Cognitive Disorders: Integrative Mechanisms Linking Neurotransmitter Systems, Neurodegeneration, and the Gut-Brain Axis. literature abstract metadata
- T2 Anxiety-related behavioural responses to light-dark transitions in zebrafish larvae treated with a Withania somnifera (L.) Dunal water extract and selected withanolides. literature abstract metadata