Devil's Bush

Eleutherococcus senticosus

Eleutherococcus senticosus, commonly known as Siberian ginseng, is a traditional medicinal plant used in East Asian and Russian herbal practices. While its specific uses are not well-documented, it has been traditionally employed for enhancing physical endurance and treating fatigue. Scientific evidence suggests that eleutheroside B, a compound found in Eleutherococcus senticosus, may alleviate depressive-like behaviors by modulating the TLR4/MyD88/NF-κB signaling pathway. Additionally, studies indicate that optimal concentrations of Penicillium oxalicum can enhance phenolic compound biosynthesis in the leaves and reduce metabolite accumulation at high concentrations. A standardized stem extract has also shown potential in attenuating dexamethasone-induced skeletal muscle atrophy by modulating FoxO3a-associated atrogene expression. No major safety concerns or known drug interactions have been recorded, but further research is needed to fully understand its therapeutic applications and potential effects.

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Beste Evidenz
D
Warnhinweise

Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.

Was die Wissenschaft sagt

  • Eleutherosid B verringerte depressivähnliche Verhaltensweisen bei Mäusen, die durch LPS ausgelöst wurden, indem es den TLR4/MyD88/NF-κB-Signalweg im Dentate Gyrus unterdrückte. D PMID
  • Eleutherococcus senticosus hält eine mittlere genetische Vielfalt auf specieslevel bei, zeigt aber erhebliche Variationen zwischen Populationen. D PMID
  • Die Studie zeigte an, dass optimale Konzentrationen von Penicillium oxalicum die Biosynthese phenolischer Verbindungen in den Blättern von Eleutherococcus senticosus verbesserten, während hohe Konzentrationen das Akkumulieren von Metaboliten unterdrückten. D PMID
  • Ein standardisierter Extrakt der Stämme von Eleutherococcus senticosus verringert die kortexinduzierte Muskelaufatrophie bei Ratten durch das Modulieren von FoxO3a-verknüpften Wegen. D PMID
  • ESF hat die Blutdruckwerte signifikant senken und den氧化应激和心脏及肾脏的病理损伤减轻,并涉及色氨酸和维生素B6代谢途径的变化。 D PMID

Frequently asked questions

What is Devil's Bush?

Devil's Bush (Eleutherococcus senticosus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Devil's Bush?

5 sourced findings are recorded for Devil's Bush; the strongest carries evidence grade D. For example: Eleutherosid B verringerte depressivähnliche Verhaltensweisen bei Mäusen, die durch LPS ausgelöst wurden, indem es den TLR4/MyD88/NF-κB-Signalweg im Dentate Gyrus unterdrückte.

How strong is the evidence for Devil's Bush?

The strongest finding for Devil's Bush carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Devil's Bush safe? What are the side effects?

No major safety issues are recorded for Devil's Bush in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Devil's Bush interact with medications?

No drug interactions are recorded for Devil's Bush in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Devil's Bush?

Devil's Bush is also known as: Элеутерококк колючий.

Is Devil's Bush a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Quellen

  1. T2 Development and Application of EST-SSR Markers to Assess Genetic Diversity and Structure of Eleutherococcus senticosus for Conservation and Breeding. literature abstract metadata
  2. T2 Integrated network pharmacology and Chinmedomics reveal the molecular mechanisms of aqueous extract of Eleutherococcus senticosus fruit for treating essential hypertension. literature abstract metadata
  3. T2 Eleutheroside B alleviates LPS-induced depressive-like behaviors by suppressing the TLR4/MyD88/NF-κB signaling pathway in the dentate gyrus. literature abstract metadata
  4. T2 Unraveling the metabolic regulation of Eleutherococcus senticosus leaves by Penicillium oxalicum: insights from targeted and non-targeted metabolomics. literature abstract metadata
  5. T2 A standardized Eleutherococcus senticosus stem extract attenuates dexamethasone-induced skeletal muscle atrophy. literature abstract metadata