Devil's Bush
Eleutherococcus senticosus
Eleutherococcus senticosus, commonly known as Siberian ginseng, is a traditional medicinal plant used in East Asian and Russian herbal practices. While its specific uses are not well-documented, it has been traditionally employed for enhancing physical endurance and treating fatigue. Scientific evidence suggests that eleutheroside B, a compound found in Eleutherococcus senticosus, may alleviate depressive-like behaviors by modulating the TLR4/MyD88/NF-κB signaling pathway. Additionally, studies indicate that optimal concentrations of Penicillium oxalicum can enhance phenolic compound biosynthesis in the leaves and reduce metabolite accumulation at high concentrations. A standardized stem extract has also shown potential in attenuating dexamethasone-induced skeletal muscle atrophy by modulating FoxO3a-associated atrogene expression. No major safety concerns or known drug interactions have been recorded, but further research is needed to fully understand its therapeutic applications and potential effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Eleutheroside B alleviated LPS-induced depressive-like behaviors in mice by suppressing the TLR4/MyD88/NF-κB signaling pathway in the dentate gyrus.
- Eleutherococcus senticosus maintains moderate genetic diversity at the species level but shows substantial variation among populations.
- The study found that optimal concentrations of Penicillium oxalicum enhanced the biosynthesis of phenolic compounds in Eleutherococcus senticosus leaves, while high concentrations suppressed metabolite accumulation.
- A standardized Eleutherococcus senticosus stem extract attenuated dexamethasone-induced skeletal muscle atrophy in rats by modulating FoxO3a-associated pathways.
- ESF significantly reduced blood pressure and alleviated oxidative stress and pathological injuries in heart and kidney, involving altered tryptophan and vitamin B6 metabolism pathways.
Frequently asked questions
What is Devil's Bush?
Devil's Bush (Eleutherococcus senticosus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Devil's Bush?
5 sourced findings are recorded for Devil's Bush; the strongest carries evidence grade D. For example: Eleutheroside B alleviated LPS-induced depressive-like behaviors in mice by suppressing the TLR4/MyD88/NF-κB signaling pathway in the dentate gyrus.
How strong is the evidence for Devil's Bush?
The strongest finding for Devil's Bush carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Devil's Bush safe? What are the side effects?
No major safety issues are recorded for Devil's Bush in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Devil's Bush interact with medications?
No drug interactions are recorded for Devil's Bush in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Devil's Bush?
Devil's Bush is also known as: Элеутерококк колючий.
Is Devil's Bush a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Development and Application of EST-SSR Markers to Assess Genetic Diversity and Structure of Eleutherococcus senticosus for Conservation and Breeding. literature abstract metadata
- T2 Integrated network pharmacology and Chinmedomics reveal the molecular mechanisms of aqueous extract of Eleutherococcus senticosus fruit for treating essential hypertension. literature abstract metadata
- T2 Eleutheroside B alleviates LPS-induced depressive-like behaviors by suppressing the TLR4/MyD88/NF-κB signaling pathway in the dentate gyrus. literature abstract metadata
- T2 Unraveling the metabolic regulation of Eleutherococcus senticosus leaves by Penicillium oxalicum: insights from targeted and non-targeted metabolomics. literature abstract metadata
- T2 A standardized Eleutherococcus senticosus stem extract attenuates dexamethasone-induced skeletal muscle atrophy. literature abstract metadata