Ajuga decumbens
Ajuga decumbens
Ajuga decumbens is a traditional medicinal plant used in various folk practices but lacks specific documented traditional uses. Scientific evidence suggests that ZY5301 tablets derived from Ajuga decumbens may show some efficacy in reducing chronic pelvic pain, though the differences between doses are not significant. Luteolin, a compound found in Ajuga decumbens, has shown potential anti-cancer effects by suppressing migration and invasion of hepatocellular carcinoma cells through specific mechanisms. Additionally, Ajuga decumbens (ADCB) demonstrated greater anti-inflammatory activities compared to controls by reducing nitric oxide and pro-inflammatory cytokines in LPS-stimulated macrophages. Arenarine D from the plant has been shown to promote mouse β cell proliferation by inhibiting DYRK1A, which could have implications for Type 1 Diabetes Mellitus therapy. No major safety concerns or recorded drug interactions are associated with Ajuga decumbens.
- Best evidence
- B
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- ZY5301 tablets from Ajuga decumbens showed some efficacy in reducing chronic pelvic pain compared to placebo, but differences between doses were not significant.
- Luteolin suppresses hepatocellular carcinoma cell migration and invasion by targeting miR-6809-5p/FLOT1/FAK and affecting EMT markers.
- ADCB demonstrated greater anti-inflammatory activities compared to the control by reducing nitric oxide and pro-inflammatory cytokines in LPS-stimulated macrophages.
- Arenarine D promotes mouse β cell proliferation by inhibiting DYRK1A, potentially useful for T1DM treatment.
Frequently asked questions
What is Ajuga decumbens?
Ajuga decumbens (Ajuga decumbens) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Ajuga decumbens?
4 sourced findings are recorded for Ajuga decumbens; the strongest carries evidence grade B. For example: ZY5301 tablets from Ajuga decumbens showed some efficacy in reducing chronic pelvic pain compared to placebo, but differences between doses were not significant.
How strong is the evidence for Ajuga decumbens?
The strongest finding for Ajuga decumbens carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Ajuga decumbens safe? What are the side effects?
No major safety issues are recorded for Ajuga decumbens in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Ajuga decumbens interact with medications?
No drug interactions are recorded for Ajuga decumbens in our sources. This does not rule them out — check with a pharmacist.
Is Ajuga decumbens a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 ZY5301 Tablet vs Placebo for Treatment of Chronic Pelvic Pain After Pelvic Inflammatory Disease: A Phase 2 Randomized Clinical Trial. literature abstract metadata
- T2 Anti-Inflammatory Effects of Ajuga decumbens Extract under Blue Light Stimulation. literature abstract metadata
- T2 Luteolin suppresses cell migration and invasion via targeting miR-6809-5p/FLOT1/FAK and eliciting EMT in hepatocellular carcinoma. literature abstract metadata
- T2 Arenarine D Promotes Pancreatic β Cell Proliferation Via DYRK1A Inhibition for T1DM Therapy. literature abstract metadata