Lady's Mantle
Alchemilla
Alchemilla is a genus of plants commonly known as lady's mantle, with traditional uses not well-documented. Scientific evidence suggests potential benefits from various extracts; for instance, an ethyl acetate extract of Alchemilla vulgaris showed promise in depigmenting zebrafish embryos more effectively and less toxically than other compounds tested. Additionally, methanolic extracts of Alchemilla alpina demonstrated antioxidant, enzyme inhibitory, receptor modulatory, and moderate cytotoxic properties. Furthermore, biosynthesized silver nanoparticles from Alchemilla vulgaris (AgNPs-Av) exhibited significant antibacterial and antibiofilm effects against staphylococci. No major safety concerns or recorded drug interactions have been identified to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Ethyl acetate extract of Alchemilla vulgaris was found to be more effective and less toxic than PTU and kojic acid for depigmenting zebrafish embryos.
- Hot water extraction was more effective than maceration for extracting polyphenols from most of the studied plant species.
- Biosynthesized AgNPs-Av inhibited bacterial growth and biofilm formation at 50 μg/mL, while subinhibitory ampicillin concentrations showed partial biofilm-eradication activity.
- The study found that the methanolic extract of Alchemilla alpina exhibited antioxidant, enzyme inhibitory, receptor modulatory, and moderate cytotoxic properties.
- The study found that N-acetylcarnosine-loaded gold nanoparticles synthesized from Alchemilla vulgaris showed enhanced antioxidant activity and improved lens optical clarity in ex-vivo cataractous lenses.
Frequently asked questions
What is Lady's Mantle?
Lady's Mantle (Alchemilla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Lady's Mantle?
5 sourced findings are recorded for Lady's Mantle; the strongest carries evidence grade D. For example: Ethyl acetate extract of Alchemilla vulgaris was found to be more effective and less toxic than PTU and kojic acid for depigmenting zebrafish embryos.
How strong is the evidence for Lady's Mantle?
The strongest finding for Lady's Mantle carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Lady's Mantle safe? What are the side effects?
No major safety issues are recorded for Lady's Mantle in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Lady's Mantle interact with medications?
No drug interactions are recorded for Lady's Mantle in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Lady's Mantle?
Lady's Mantle is also known as: Манжетка, alchémille.
Is Lady's Mantle a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 The Influence of Water Extraction Methods on the Isolation of Polyphenols and Tannins from Various Ericaceae and Rosaceae Species. literature abstract metadata
- T2 Green-synthesized N-acetylcarnosine-loaded gold nanoparticles as a novel ocular nanocarrier for antioxidant therapy and cataract prevention. literature abstract metadata
- T2 Effect of Biosynthesized Gold and Silver Nanoparticles Using Alchemilla vulgaris Extract and Their Synergistic Action with Subinhibitory Concentrations of Ampicillin Against Staphylococci. literature abstract metadata
- T2 Bioactivities of Alchemilla alpina L. Extract on Women's Reproductive and Metabolic Health: Antioxidant, Enzyme Inhibitory, Receptor Modulatory Properties and Potential Cytotoxic Effects. literature abstract metadata
- T2 A Safe Natural Alternative to Phenylthiourea: Ethyl Acetate Extract of Alchemilla vulgaris for Zebrafish Embryo Depigmentation. literature abstract metadata