Bishop's Weed
Ammi majus
Ammi majus, a plant traditionally used in various herbal practices but lacking specific documented uses, has been studied for its biological and biochemical properties. Research indicates that it contains genes involved in the biosynthesis of furanocoumarins, with higher expression levels observed in immature fruit compared to vegetative leaves. Scientific evidence also suggests potential therapeutic benefits, as methanolic extracts from both Ammi majus and Ammi visnaga have shown effectiveness in alleviating hyperthyroidism induced by L-thyroxine in rats, though the findings are preliminary and require further validation. The plant's genome has been sequenced for a potyvirus (AMLV-CQ) that infects culantro, highlighting its genetic relatedness to AMLV-WF17. Additionally, compounds from Ammi majus, such as bergapten and imperatorin, have demonstrated potent inhibition of PTP1B with IC50 values comparable to ursolic acid, indicating potential for future research in this area. No major safety concerns or recorded drug interactions are currently known, but further studies are warranted to fully understand its safety profile and potential applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified genes involved in the biosynthesis of furanocoumarins in Ammi majus, with higher expression in immature fruit compared to vegetative leaves.
- Both Ammi visnaga and Ammi majus at low and high doses effectively alleviated L-thyroxine-induced hyperthyroidism in rats, as indicated by hormonal and metabolic assessments.
- Bergapten and Imperatorin from Ammi majus showed potent in vitro inhibition of PTP1B with IC50 values comparable to the reference inhibitor ursolic acid.
- The study determined the complete genome sequence of a potyvirus (AMLV-CQ) infecting culantro, identifying it as a new natural host for this virus.
Frequently asked questions
What is Bishop's Weed?
Bishop's Weed (Ammi majus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bishop's Weed?
4 sourced findings are recorded for Bishop's Weed; the strongest carries evidence grade D. For example: The study identified genes involved in the biosynthesis of furanocoumarins in Ammi majus, with higher expression in immature fruit compared to vegetative leaves.
How strong is the evidence for Bishop's Weed?
The strongest finding for Bishop's Weed carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Bishop's Weed safe? What are the side effects?
No major safety issues are recorded for Bishop's Weed in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bishop's Weed interact with medications?
No drug interactions are recorded for Bishop's Weed in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bishop's Weed?
Bishop's Weed is also known as: Амми большая, Ammi élevé.
Is Bishop's Weed a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Integrated Metabolome and Transcriptome Analysis in Ammi majus L. Revealed Candidate Genes of Furanocoumarins Pathway. literature abstract metadata
- T2 Coumarin-Based Allosteric Inhibition of PTP1B: A Potential Strategy for Metabolic Regulation. literature abstract metadata
- T2 The first complete genome sequence of Ammi majus latent virus from the new natural host culantro. literature abstract metadata
- T2 Ammi visnaga (Visnaga daucoides) & Ammi majus as a novel thyrotherapeutic phytoalternative for rat with L-thyroxine-induced hyperthyroidism. literature abstract metadata