King Fern
Angiopteris evecta
Angiopteris evecta, commonly known as the giant fern or king fern, is a traditional plant found in tropical and subtropical regions of Southeast Asia. While its use in traditional medicine has not been extensively documented, studies have shown promising results with compounds isolated from this plant. Research indicates that furanone compounds from Angiopteris evecta can significantly suppress NSCLC cell viability and induce apoptosis through modulation of the MAPK pathway, suggesting potential anti-cancer properties. Additionally, angiopteroside, a compound isolated from the rhizome, has been found to exhibit potent anti-inflammatory and anti-leukemic activities. The structural analysis reveals that Angiopteris evecta shares an ordered architectural pattern with its fossil relative Weichselia reticulata, highlighting its evolutionary significance. Notably, no major safety concerns or drug interactions have been recorded for this plant, though further research is warranted to fully understand its potential applications and effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- AE-EA and OLRF from Angiopteris evecta significantly suppressed NSCLC cell viability and induced intrinsic apoptosis via MAPK pathway modulation.
- The study identified a furanone compound from Angiopteris evecta with potent anti-inflammatory and anti-leukemic activities.
- The study found that the fossil fern Weichselia reticulata shares an ordered architectural pattern with modern ferns like Angiopteris evecta.
- The study found that angiopteroside can be isolated from the rhizome of Angiopteris evecta with a yield of 9.9%.
Frequently asked questions
What is King Fern?
King Fern (Angiopteris evecta) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about King Fern?
4 sourced findings are recorded for King Fern; the strongest carries evidence grade D. For example: AE-EA and OLRF from Angiopteris evecta significantly suppressed NSCLC cell viability and induced intrinsic apoptosis via MAPK pathway modulation.
How strong is the evidence for King Fern?
The strongest finding for King Fern carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is King Fern safe? What are the side effects?
No major safety issues are recorded for King Fern in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does King Fern interact with medications?
No drug interactions are recorded for King Fern in our sources. This does not rule them out — check with a pharmacist.
Is King Fern a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Two-dimensional NMR analysis of Angiopteris evecta rhizome and improved extraction method for angiopteroside. literature abstract metadata
- T2 A novel approach for the metric analysis of fern fronds: Growth and architecture of the Mesozoic fern Weichselia reticulata in the light of modern ferns. literature abstract metadata
- T2 Isolation and Characterization of 5-(1-Hydroxyethyl)-Dihydro-2-Furanone from Angiopteris evecta with Potent Anti-Inflammatory and Anti-Leukemic Activities. literature abstract metadata
- T2 (-)-Epi-Osmundalactone-Rich Fraction from Angiopteris evecta Suppresses Proliferation and Induces Intrinsic Apoptosis in Non-Small Cell Lung Cancer Cells via MAPK Pathway Modulation. literature abstract metadata