FolkKB

King Fern

Angiopteris evecta

Angiopteris evecta, commonly known as the giant fern or elephant ear fern, is an ancient species with a long evolutionary history. While it has not been traditionally used in any specific medicinal practices, recent scientific studies have shown promising results. Research indicates that compounds from Angiopteris evecta may suppress non-small cell lung cancer (NSCLC) cell viability and induce intrinsic apoptosis through modulation of the MAPK pathway. Additionally, a furanone compound was identified with potent anti-inflammatory and anti-leukemic activities. The study also noted similarities between the fossil fern Weichselia reticulata and modern Angiopteris evecta in their ordered architectural patterns, suggesting potential shared biological properties. Safety-wise, no major issues have been recorded; however, further research is needed to fully understand its safety profile. There are currently no reported drug interactions, but this area requires additional investigation for comprehensive understanding.

At a glance
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • AE-EA and OLRF from Angiopteris evecta significantly suppressed NSCLC cell viability and induced intrinsic apoptosis via MAPK pathway modulation. D PMID
  • The study identified a furanone compound from Angiopteris evecta with potent anti-inflammatory and anti-leukemic activities. D PMID
  • The study found that the fossil fern Weichselia reticulata shares an ordered architectural pattern with modern ferns like Angiopteris evecta. D PMID
  • The study found that angiopteroside can be isolated from the rhizome of Angiopteris evecta with a yield of 9.9%. D PMID

Frequently asked questions

What is King Fern?

King Fern (Angiopteris evecta) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about King Fern?

4 sourced findings are recorded for King Fern; the strongest carries evidence grade D. For example: AE-EA and OLRF from Angiopteris evecta significantly suppressed NSCLC cell viability and induced intrinsic apoptosis via MAPK pathway modulation.

How strong is the evidence for King Fern?

The strongest finding for King Fern carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is King Fern safe? What are the side effects?

No major safety issues are recorded for King Fern in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does King Fern interact with medications?

No drug interactions are recorded for King Fern in our sources. This does not rule them out — check with a pharmacist.

Is King Fern a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Two-dimensional NMR analysis of Angiopteris evecta rhizome and improved extraction method for angiopteroside. literature abstract metadata
  2. T2 A novel approach for the metric analysis of fern fronds: Growth and architecture of the Mesozoic fern Weichselia reticulata in the light of modern ferns. literature abstract metadata
  3. T2 Isolation and Characterization of 5-(1-Hydroxyethyl)-Dihydro-2-Furanone from Angiopteris evecta with Potent Anti-Inflammatory and Anti-Leukemic Activities. literature abstract metadata
  4. T2 (-)-Epi-Osmundalactone-Rich Fraction from Angiopteris evecta Suppresses Proliferation and Induces Intrinsic Apoptosis in Non-Small Cell Lung Cancer Cells via MAPK Pathway Modulation. literature abstract metadata