Japanese Angelica Tree
Aralia elata
Aralia elata, a plant traditionally used in East Asian medicine, particularly in Korea and China, is known for its potential health benefits. Traditionally, it has been utilized for various purposes such as treating rheumatism and enhancing overall well-being, though specific uses vary across different traditions. Scientific evidence indicates that compounds derived from Aralia elata, notably Calenduloside E (CE) and its derivative C5, show promising anti-atherosclerotic properties by inhibiting phosphoglycerate kinase 1 and protecting against ox-LDL-induced injury in endothelial cells, respectively. Additionally, leaf extracts have demonstrated efficacy in synthesizing ZnO-based nanoclusters for wastewater treatment and showed potential benefits in reducing airway inflammation and mucus hypersecretion in asthmatic mice models. However, the evidence is currently limited to animal studies and preliminary findings, so further research is needed to confirm these effects. No major safety concerns or drug interactions have been reported thus far.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Aralia elata compound Calenduloside E (CE) shows potent anti-atherosclerotic activity by inhibiting phosphoglycerate kinase 1 (PGK1).
- A derivative (C5) of Aralia elata's Calenduloside E showed protective activity against ox-LDL-induced HUVECs injury by targeting HSP90β.
- Aralia elata leaf extracts were used to synthesize ZnO-based nanoclusters that efficiently removed organic dyes from wastewater.
- GA treatment in asthmatic mice showed reduced airway inflammation and mucus hypersecretion with altered cytokine levels and gene expression.
Frequently asked questions
What is Japanese Angelica Tree?
Japanese Angelica Tree (Aralia elata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Japanese Angelica Tree?
4 sourced findings are recorded for Japanese Angelica Tree; the strongest carries evidence grade D. For example: Aralia elata compound Calenduloside E (CE) shows potent anti-atherosclerotic activity by inhibiting phosphoglycerate kinase 1 (PGK1).
How strong is the evidence for Japanese Angelica Tree?
The strongest finding for Japanese Angelica Tree carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Japanese Angelica Tree safe? What are the side effects?
No major safety issues are recorded for Japanese Angelica Tree in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Japanese Angelica Tree interact with medications?
No drug interactions are recorded for Japanese Angelica Tree in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Japanese Angelica Tree?
Japanese Angelica Tree is also known as: Аралия высокая, Angelique du Japon.
Is Japanese Angelica Tree a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Discovery of Calenduloside E (CE) and its derivatives as the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) inhibitors for suppressing atherogenesis. literature abstract metadata
- T2 Discovery and Evaluation of Novel Calenduloside E Derivatives Targeting HSP90β in Ox-LDL-Induced HUVECs Injury. literature abstract metadata
- T2 Ameliorative effects of total glycosides from Aralia elata on airway inflammation and mucus hypersecretion in asthmatic mice. literature abstract metadata
- T2 Aralia elata leaf extracts synthesize ZnO-based nanoclusters and their dye removal applications. literature abstract metadata