American paw paw
Asimina triloba
Asimina triloba, commonly known as pawpaw, is a traditional North American tree that has been studied for its genetic and potential medicinal properties. While there are no documented traditional uses of Asimina triloba in any specific medical traditions, recent scientific research has shown promising results. A high-quality genome assembly has been produced, offering valuable resources for future studies and breeding programs. Additionally, a novel cyclopeptide named Asiminatide A from this plant, delivered via a nanoparticle system, demonstrated enhanced efficacy against triple-negative breast cancer in both laboratory and animal models. The plant also exhibits a late-acting self-incompatibility system involving arrested embryo development and fruitlet abscission following auto-incompatible pollination. Furthermore, a polysaccharide extracted from the fruits of Asimina triloba has shown potential in alleviating symptoms of ulcerative colitis by modulating inflammatory signaling and gut microbiota. No major safety concerns or known drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study provides evidence for a late-acting self-incompatibility system in Asimina triloba, involving arrested embryo development and fruitlet abscission following auto-incompatible pollination.
- The study produced the first high-quality genome assembly of the pawpaw tree (Asimina triloba), providing genetic resources for future research.
- The study found that a novel cyclopeptide from Asimina triloba, encapsulated in nanoparticles, showed enhanced efficacy against triple-negative breast cancer in vitro and in vivo.
- A polysaccharide from Asimina triloba fruits showed promise in alleviating symptoms of ulcerative colitis by modulating inflammatory signaling and gut microbiota.
Frequently asked questions
What is American paw paw?
American paw paw (Asimina triloba) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about American paw paw?
4 sourced findings are recorded for American paw paw; the strongest carries evidence grade D. For example: The study provides evidence for a late-acting self-incompatibility system in Asimina triloba, involving arrested embryo development and fruitlet abscission following auto-incompatible pollination.
How strong is the evidence for American paw paw?
The strongest finding for American paw paw carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is American paw paw safe? What are the side effects?
No major safety issues are recorded for American paw paw in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does American paw paw interact with medications?
No drug interactions are recorded for American paw paw in our sources. This does not rule them out — check with a pharmacist.
What are the common names of American paw paw?
American paw paw is also known as: Азимина трёхлопастная, asiminier trilobé.
Is American paw paw a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Polysaccharide from Asimina triloba fruits alleviates DSS-induced ulcerative colitis by modulating inflammatory signaling and gut microbiota. literature abstract metadata
- T2 Late-acting self-incompatibility in Asimina triloba: implications for the evolution of self-incompatibility in angiosperms. literature abstract metadata
- T2 Enhanced Anticancer Efficacy of Novel Asiminatide A Isolated from Asimina triloba in Triple-Negative Breast Cancer. literature abstract metadata
- T2 First genome and transcription factor profile for Asimina triloba, a native North American fruit tree. literature abstract metadata