Korean astilbe
Astilbe grandis
Astilbe grandis is a plant traditionally not associated with any specific medicinal use. Scientific evidence suggests that compounds from Astilbe grandis may have anti-inflammatory properties, as demonstrated by their ability to inhibit inflammatory responses in cell cultures and suppress the NF-κB signaling pathway. Additionally, triterpene compounds found in its roots exhibit varying levels of cytotoxicity against certain tumor cells, indicating potential anti-tumor activity. However, these findings are preliminary and more research is needed to confirm these effects in vivo. No significant safety concerns or known drug interactions have been reported for Astilbe grandis, but further studies are warranted to fully understand its potential benefits and risks.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Two compounds from Astilbe grandis inhibited inflammatory markers and NF-κB activation in RAW264.7 cells.
- Astilbe grandis triterpenes showed varying cytotoxicity against Caco-2 tumor cells with IC50 values less than 10 μM.
- Compounds from Astilbe grandis significantly inhibited LPS-induced macrophage activation by suppressing the NF-κB signaling pathway.
- Astilbe grandis roots contain six triterpenes, some showing moderate anti-tumor activity against certain cell lines.
Frequently asked questions
What is Korean astilbe?
Korean astilbe (Astilbe grandis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Korean astilbe?
4 sourced findings are recorded for Korean astilbe; the strongest carries evidence grade D. For example: Two compounds from Astilbe grandis inhibited inflammatory markers and NF-κB activation in RAW264.7 cells.
How strong is the evidence for Korean astilbe?
The strongest finding for Korean astilbe carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Korean astilbe safe? What are the side effects?
No major safety issues are recorded for Korean astilbe in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Korean astilbe interact with medications?
No drug interactions are recorded for Korean astilbe in our sources. This does not rule them out — check with a pharmacist.
Is Korean astilbe a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Triterpenoid acids characterized by the oxidation of the C-27-methy from the roots of Astilbe grandis Stapf ex Wils. literature abstract metadata
- T2 Triterpenoid and Coumarin Isolated from Astilbe grandis with Anti-Inflammatory Effects through Inhibiting the NF-κB Pathway in LPS-Induced RAW264.7 Cells. literature abstract metadata
- T2 Structures and Tumor Cell Lines Proliferation Activities of Triterpenes Isolated from Astilbe grandis. literature abstract metadata
- T2 Oleanane triterpenoids with C-14 carboxyl group from Astilbe grandis inhibited LPS-induced macrophages activation by suppressing the NF-κB signaling pathway. literature abstract metadata