Common Hedge Hyssop
Gratiola officinalis
Gratiola officinalis, commonly known as common bladderwort, is a plant traditionally used in various European folk medicine practices. While specific traditional uses are not well-documented, its inclusion among plants with high ethnopediatric relative therapeutic versatility suggests broad historical use, possibly for pediatric conditions. Scientific evidence indicates that Gratiola officinalis contains antitumor-active flavonoid fractions, which have shown significant cell death in breast and cervical cancer cells. Additionally, the extract has demonstrated differential effects on colorectal cancer cells by inducing apoptosis, inhibiting glycolysis, and causing cell cycle arrest. Safety data for Gratiola officinalis is currently limited, with no major issues recorded; however, further research is needed to fully understand its potential benefits and risks. There are no known drug interactions reported at this time.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Two antitumor-active flavonoid fractions were identified from Gratiola officinalis extract.
- The encapsulated Gratiola officinalis extract caused significant cell death in breast cancer SKBR-3 cells and partial death in cervical cancer HeLa cells.
- Gratiola officinalis was found among plants with high ethnopediatric relative therapeutic versatility, indicating broad traditional use.
- Gratiola officinalis extract showed differential effects on colorectal cancer cell lines, inducing apoptosis, inhibiting glycolysis, and causing cell cycle arrest.
Frequently asked questions
What is Common Hedge Hyssop?
Common Hedge Hyssop (Gratiola officinalis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Common Hedge Hyssop?
4 sourced findings are recorded for Common Hedge Hyssop; the strongest carries evidence grade D. For example: Two antitumor-active flavonoid fractions were identified from Gratiola officinalis extract.
How strong is the evidence for Common Hedge Hyssop?
The strongest finding for Common Hedge Hyssop carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Common Hedge Hyssop safe? What are the side effects?
No major safety issues are recorded for Common Hedge Hyssop in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Common Hedge Hyssop interact with medications?
No drug interactions are recorded for Common Hedge Hyssop in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Common Hedge Hyssop?
Common Hedge Hyssop is also known as: Авран лекарственный, Gratiole Officinale.
Is Common Hedge Hyssop a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s-1970s). literature abstract metadata
- T2 Antitumor Effects of Microencapsulated Gratiola officinalis Extract on Breast Carcinoma and Human Cervical Cancer Cells In Vitro. literature abstract metadata
- T2 Composition and Biological Activity of Flavonoid-containing Fractions of an Extract from Gratiola officinalis L. literature abstract metadata
- T2 Gratiola officinalis Alcoholic Extract Targets Warburg Effect, Apoptosis and Cell Cycle Progression in Colorectal Cancer Cell Lines. literature abstract metadata