FolkKB

Griffonia simplicifolia

Griffonia simplicifolia

Griffonia simplicifolia is an African plant traditionally used in various herbal remedies but lacks specific documented traditional uses. Scientific evidence suggests limited effects on pain mechanisms and some potential in blocking inflammatory and epigenetic signals in osteosarcoma cells, though the findings are not strongly conclusive. The extract also showed modulation of macrophage polarization towards a proangiogenic phenotype post-myocardial infarction in mice studies, with gender differences noted but results are mixed. Safety profiles indicate no major issues have been recorded, and there is currently no evidence of significant drug interactions.

At a glance
Best evidence
B
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • Acute vericiguat administration post-myocardial infarction modulated macrophage polarization towards a proangiogenic phenotype, more pronounced in females. D PMID
  • Griffonia simplicifolia showed limited effects on experimentally induced pain mechanisms compared to placebo in this study. B PMID
  • The study found that yes-associated protein drives H. pylori-induced metaplastic changes in gastric epithelium, with OTU deubiquitinase, ubiquitin aldehyde binding 2 playing an upstream regulatory role. D PMID
  • The Griffonia simplicifolia seed extract showed some ability to block inflammatory signals and interact epigenetically without interfering with doxorubicin's effects in osteosarcoma cells. D PMID

Frequently asked questions

What is Griffonia simplicifolia?

Griffonia simplicifolia (Griffonia simplicifolia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Griffonia simplicifolia?

4 sourced findings are recorded for Griffonia simplicifolia; the strongest carries evidence grade B. For example: Acute vericiguat administration post-myocardial infarction modulated macrophage polarization towards a proangiogenic phenotype, more pronounced in females.

How strong is the evidence for Griffonia simplicifolia?

The strongest finding for Griffonia simplicifolia carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Griffonia simplicifolia safe? What are the side effects?

No major safety issues are recorded for Griffonia simplicifolia in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Griffonia simplicifolia interact with medications?

No drug interactions are recorded for Griffonia simplicifolia in our sources. This does not rule them out — check with a pharmacist.

Is Griffonia simplicifolia a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Modulation of macrophage polarization with acute administration of Vericiguat after myocardial infarction. literature abstract metadata
  2. T2 Antimetastatic Effects of a Griffonia simplicifolia Seed Extract in Osteosarcoma Cell Lines. literature abstract metadata
  3. T2 Yes-Associated Protein Drives Helicobacter pylori-Induced Metaplastic Changes in Gastric Epithelium. literature abstract metadata
  4. T2 The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. literature abstract metadata