Broad-leaved Sermountain
Laserpitium
Laserpitium, primarily associated with traditional medicine practices in Europe, particularly in Italy and Greece, has not been extensively documented for specific medicinal uses. However, scientific research has identified several bioactive compounds within Laserpitium species, such as archangelolide from *Laserpitium archangelica*, which demonstrated anti-inflammatory activity without cytotoxic effects. Additionally, studies isolated new nordaucane sesquiterpene and sesquiterpene lactone from various Laserpitium species, showing both in vitro and in vivo anti-cancer properties. Essential oils from *Laserpitium siler subsp. siculum* and *Calendula incana subsp. maritima* exhibited varying levels of toxicity against stored product pests, with *C. maritima* showing slightly higher activity against certain pests. The sesquiterpene lactones from the roots of *Laserpitium siler subsp. siculum* induced apoptosis and oxidative stress in breast cancer cells. To date, no major safety issues or recorded drug interactions have been reported for Laserpitium.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified cytotoxic sesquiterpene lactones from Laserpitium siler subsp. siculum roots that induced apoptosis and oxidative stress in breast cancer cells.
- Archangelolide, a sesquiterpene lactone from Laserpitium archangelica, showed anti-inflammatory activity but no cytotoxic effects in the studied cells.
- The study isolated several bioactive compounds from Laserpitium species, including new nordaucane sesquiterpene and identified their in vitro and in vivo anticancer activities.
- Laserpitium siler subsp. siculum essential oil showed lower insecticidal activity against stored product pests compared to Calendula incana subsp. maritima oil, which had higher activity against Sitophilus oryzae and Rhyzoperta dominica.
Frequently asked questions
What is Broad-leaved Sermountain?
Broad-leaved Sermountain (Laserpitium) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Broad-leaved Sermountain?
4 sourced findings are recorded for Broad-leaved Sermountain; the strongest carries evidence grade D. For example: The study identified cytotoxic sesquiterpene lactones from Laserpitium siler subsp. siculum roots that induced apoptosis and oxidative stress in breast cancer cells.
How strong is the evidence for Broad-leaved Sermountain?
The strongest finding for Broad-leaved Sermountain carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Broad-leaved Sermountain safe? What are the side effects?
No major safety issues are recorded for Broad-leaved Sermountain in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Broad-leaved Sermountain interact with medications?
No drug interactions are recorded for Broad-leaved Sermountain in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Broad-leaved Sermountain?
Broad-leaved Sermountain is also known as: Гладыш (растение), Laser.
Is Broad-leaved Sermountain a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Archangelolide: A sesquiterpene lactone with immunobiological potential from Laserpitium archangelica. literature abstract metadata
- T2 Chemical Composition and Evaluation of Insecticidal Activity of Calendula incana subsp. maritima and Laserpitium siler subsp. siculum Essential Oils against Stored Products Pests. literature abstract metadata
- T2 Novel Nordaucane Sesquiterpenoid and Sesquiterpene Lactone From Laserpitium Species: Isolation, Structure Elucidation, In Vitro, In Vivo, and In Silico Evaluation as Anticancer Agents. literature abstract metadata
- T2 Exploring the Biochemical Mechanism Beyond the Cytotoxic Activity of Sesquiterpene Lactones from Sicilian Accession of Laserpitium siler Subsp. siculum (Spreng.) Thell. literature abstract metadata