East Asian mallotus
Mallotus japonicus
Mallotus japonicus, a plant traditionally unrecorded for medicinal use, has been studied for its biological activities. Scientific investigations have shown that it can alter the phyllosphere fungal community composition on the plant, though the impact on OTU richness remains uncertain. Additionally, rottlerin, a compound found in Mallotus japonicus, demonstrated potential by decreasing lipid accumulation and inhibiting de novo lipogenesis and adipogenesis through the LRP6/mTOR/SREBP1C pathway in 3T3-L1 adipocytes. RNA-seq analysis revealed two novel RNA viruses, MjVA and MjVB, within the plant. Extracts from Mallotus japonicus also exhibited ferroptosis suppression in HK2 cells by inhibiting transferrin receptor-mediated iron uptake. To date, no significant safety concerns or drug interactions have been reported for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Exclusion of ants changed the phyllosphere fungal community composition on Mallotus japonicus, but the effect on OTU richness was unclear.
- Rottlerin decreased lipid accumulation and inhibited de novo lipogenesis and adipogenesis via the LRP6/mTOR/SREBP1C pathway in 3T3-L1 adipocytes.
- The study identified two novel RNA viruses, MjVA and MjVB, in Mallotus japonicus using RNA-seq analysis.
- Mallotus japonicus extract suppresses ferroptosis in HK2 cells by inhibiting transferrin receptor-mediated Fe uptake.
Frequently asked questions
What is East Asian mallotus?
East Asian mallotus (Mallotus japonicus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about East Asian mallotus?
4 sourced findings are recorded for East Asian mallotus; the strongest carries evidence grade D. For example: Exclusion of ants changed the phyllosphere fungal community composition on Mallotus japonicus, but the effect on OTU richness was unclear.
How strong is the evidence for East Asian mallotus?
The strongest finding for East Asian mallotus carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is East Asian mallotus safe? What are the side effects?
No major safety issues are recorded for East Asian mallotus in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does East Asian mallotus interact with medications?
No drug interactions are recorded for East Asian mallotus in our sources. This does not rule them out — check with a pharmacist.
What are the common names of East Asian mallotus?
East Asian mallotus is also known as: Маллотус японский.
Is East Asian mallotus a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 High-throughput RNA sequencing analysis of Mallotus japonicus revealed novel polerovirus and amalgavirus. literature abstract metadata
- T2 Rottlerin suppresses lipid accumulation by inhibiting de novo lipogenesis and adipogenesis via LRP6/mTOR/SREBP1C in 3T3-L1 adipocytes. literature abstract metadata
- T2 Foraging ants affect community composition and diversity of phyllosphere fungi on a myrmecophilous plants, Mallotus japonicus. literature abstract metadata
- T2 Mallotus japonicus extract suppresses ferroptosis by inhibiting transferrin receptor-mediated ferrous ion uptake in human tubular epithelial HK2 cells. literature abstract metadata