Mandragora
Mandragora
Mandragora is a traditional plant with roots tracing back to various cultures, though specific medicinal uses are not well-documented. Scientific studies have shown that Mandragora autumnalis exhibits concentration- and time-dependent cytotoxic effects on certain cancer cell lines, potentially due to its phytochemical content. The plant contains various compounds with diverse pharmacological activities including antioxidant, antimicrobial, antidiabetic, anticancer, and enzyme-inhibitory properties. Ethanol extracts of Mandragora autumnalis have also demonstrated anti-inflammatory activity by modulating inflammatory mediators and pathways in macrophages. No significant safety concerns or recorded drug interactions are currently known for this plant, though further research is warranted to fully understand its potential benefits and risks.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- MAE from Mandragora autumnalis showed concentration- and time-dependent cytotoxic effects on MDA-MB-231 cells, reducing viability and altering cellular processes linked to metastasis.
- Mandragora autumnalis contains various phytochemicals with pharmacological properties including antioxidant, antimicrobial, antidiabetic, anticancer, and enzyme-inhibitory activities.
- MAE-AuNPs showed potential as antioxidant and anticancer agents through radical scavenging activity and effectiveness against cancer cell lines.
- Mandragora autumnalis ethanolic extract showed anti-inflammatory activity by inhibiting protein denaturation, stabilizing cell membranes, and downregulating inflammatory mediators and pathways in macrophages.
Frequently asked questions
What is Mandragora?
Mandragora (Mandragora) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Mandragora?
4 sourced findings are recorded for Mandragora; the strongest carries evidence grade D. For example: MAE from Mandragora autumnalis showed concentration- and time-dependent cytotoxic effects on MDA-MB-231 cells, reducing viability and altering cellular processes linked to metastasis.
How strong is the evidence for Mandragora?
The strongest finding for Mandragora carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Mandragora safe? What are the side effects?
No major safety issues are recorded for Mandragora in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Mandragora interact with medications?
No drug interactions are recorded for Mandragora in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Mandragora?
Mandragora is also known as: Мандрагора, Mandragore.
Is Mandragora a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Mandragora autumnalis Distribution, Phytochemical Characteristics, and Pharmacological Bioactivities. literature abstract metadata
- T2 Mandragora autumnalis: Phytochemical Composition, Antioxidant and Anti-Cancerous Bioactivities on Triple-Negative Breast Cancer Cells. literature abstract metadata
- T2 Green Synthesis of Gold Nanoparticles Using Mandragora autumnalis: Characterization and Evaluation of Its Antioxidant and Anticancer Bioactivities. literature abstract metadata
- T2 Anti-Inflammatory Activity of Mandragora autumnalis Ethanolic Extract: In Vitro and Cellular Mechanistic Insights. literature abstract metadata