Panax notoginseng
Panax notoginseng
Panax notoginseng, also known as Sanqi, is a traditional Chinese medicinal plant. It has been used in Chinese medicine for centuries to treat various conditions such as injuries and bleeding disorders. Scientific evidence suggests that Panax notoginseng may have beneficial effects on colitis, with studies showing a significant reduction in saponin metabolites, particularly deglycosylated products, in rats. Additionally, it appears to improve coronary heart disease by modulating lipid metabolism, gut microbiota, and PI3K/AKT signaling pathways. In diabetic nephropathy models, Panax notoginseng has been shown to significantly enhance kidney function while modulating inflammatory, oxidative stress, glucose, lipid, and fibrosis markers. However, no significant adverse effects or drug interactions have been reported in the available literature.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found a significant reduction in Panax notoginseng saponin metabolites, particularly deglycosylated products, in rats with colitis.
- G-Rh2 improved coronary heart disease in rats by modulating lipid metabolism, gut microbiota, and PI3K/AKT signaling.
- Panax notoginseng significantly improved kidney function and modulated inflammatory, oxidative stress, glucose, lipid, and fibrosis markers in diabetic nephropathy animal models.
- The study found that Qishen Yiqi Dripping Pills alleviate myocardial ischemia-reperfusion-induced fibrotic injury by targeting the TGF-β/Periostin axis.
- The study identified PnMYB38 as a key transcription factor regulating methyl jasmonate-induced saponin biosynthesis in Panax notoginseng.
- A novel totivirus, Actinidia totivirus 1 (AcToV1), was identified in kiwifruit plants and shares similarities with Panax notoginseng virus A.
Frequently asked questions
What is Panax notoginseng?
Panax notoginseng (Panax notoginseng) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Panax notoginseng?
6 sourced findings are recorded for Panax notoginseng; the strongest carries evidence grade A. For example: The study found a significant reduction in Panax notoginseng saponin metabolites, particularly deglycosylated products, in rats with colitis.
How strong is the evidence for Panax notoginseng?
The strongest finding for Panax notoginseng carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Panax notoginseng safe? What are the side effects?
No major safety issues are recorded for Panax notoginseng in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Panax notoginseng interact with medications?
No drug interactions are recorded for Panax notoginseng in our sources. This does not rule them out — check with a pharmacist.
Is Panax notoginseng a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 The effects of Panax notoginseng for the treatment of diabetic nephropathy in animals: a systematic review and meta-analysis. literature abstract metadata
- T2 The transcription factor PnMYB38 orchestrates methyl jasmonate-induced saponin biosynthesis in Panax notoginseng. literature abstract metadata
- T2 Qishen Yiqi Dripping Pills Alleviate Myocardial Ischemia-Reperfusion-Induced Fibrotic Injury by Inhibiting Fibroblast Activation via the Transforming Growth Factor-Beta/Periostin Pathway. literature abstract metadata
- T2 Genomic characterization of Actinidia totivirus 1 (AcToV1), a novel member of the genus Totivirus infecting kiwifruit. literature abstract metadata
- T2 Ginsenoside Rh2 Regulates PI3K/AKT Signaling, Metabolic Pathways, and the Gut Microbiota for Coronary Heart Disease Therapy. literature abstract metadata
- T2 Metabolic Profiling of Panax notoginseng Saponins in Rat Feces Under Colitis by UHPLC-QTOF-MS/MS. literature abstract metadata