Love Apple
Paris polyphylla
Paris polyphylla is a traditional Chinese medicinal plant that has not been extensively documented in historical or cultural medical traditions for specific uses. Scientific research indicates potential antitumor effects, particularly through mechanisms involving autophagy-dependent ferroptosis in cervical cancer cells and modulation of signaling pathways relevant to colorectal cancer. However, the evidence base remains limited and more studies are needed to confirm these findings. No significant safety concerns or drug interactions have been reported for Paris polyphylla, but further research is warranted to fully understand its potential applications and effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- PPSⅡ induces autophagy-dependent ferroptosis in cervical cancer cells via the BECLIN1/SLC7A11 axis and shows antitumor efficacy with low toxicity.
- The ethyl acetate crude extract of Sphingobium xenophagum J-1 fermentation broth showed significant inhibition of Fusarium oxysporum spore germination.
- A network pharmacology and molecular docking approach suggested that Paris polyphylla may exert anticancer effects against colorectal cancer by targeting several key pathways and proteins, though experimental validation is needed.
- The study found significant differences in furostanosides and polyhydroxylated steroidal saponins between Paris polyphylla var. chinensis and var. yunnanensis.
Frequently asked questions
What is Love Apple?
Love Apple (Paris polyphylla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Love Apple?
4 sourced findings are recorded for Love Apple; the strongest carries evidence grade D. For example: PPSⅡ induces autophagy-dependent ferroptosis in cervical cancer cells via the BECLIN1/SLC7A11 axis and shows antitumor efficacy with low toxicity.
How strong is the evidence for Love Apple?
The strongest finding for Love Apple carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Love Apple safe? What are the side effects?
No major safety issues are recorded for Love Apple in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Love Apple interact with medications?
No drug interactions are recorded for Love Apple in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Love Apple?
Love Apple is also known as: Вороний глаз многолистный.
Is Love Apple a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Comprehensive exploration and comparison of chemical constituents of Paris polyphylla var. chinensis and Paris polyphylla var. yunnanensis through two-dimensional chromatography, metabolomic analysis and furostanosides quantitation. literature abstract metadata
- T2 Network Pharmacology and Molecular Docking-Based Approach Revealing the Potential Anticancer Compounds and Molecular Mechanisms of Paris polyphylla Against Colorectal Cancer. literature abstract metadata
- T2 Paris polyphylla saponin Ⅱ induces autophagy-associated ferroptosis by regulating the BECLIN1/SLC7A11 axis in cervical cancer. literature abstract metadata
- T2 Biocontrol potential of endophytic Sphingobium xenophagum J-1 against Fusarium oxysporum causing root rot in Paris polyphylla var. yunnanensis. literature abstract metadata