Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South
Pueraria montana var. lobata
Pueraria montana var. lobata, also known as kudzu, is a traditional plant used in East Asian medicine, particularly in China and Japan. It has been traditionally utilized for various purposes such as treating alcoholism, fever, and headaches, but specific uses vary widely across different traditions and no clear traditional use can be definitively stated for this particular variety. Scientific evidence suggests that Pueraria montana var. lobata extract may have beneficial effects on liver health by reducing lipid accumulation and inflammation in mice with diet-induced liver disease. Additionally, it has shown potential in promoting myogenic differentiation and protecting against muscle atrophy induced by dexamethasone. The chloroform extract of the plant also demonstrated anti-inflammatory activity through modulating HSP90AA1/MAPK/mTOR/NF-κB signaling pathways, though these findings are still preliminary. Safety-wise, no major issues have been recorded for Pueraria montana var. lobata; however, more extensive human studies are needed to fully assess potential risks and side effects. There is currently no reported evidence of drug interactions with this plant, but further research in this area would be beneficial.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Pueraria montana var. lobata extract reduced lipid accumulation and inflammation in mice with diet-induced liver disease.
- PMLE promoted myogenic differentiation and protected against dexamethasone-induced muscle atrophy by regulating key molecular pathways.
- The chloroform extract of Pueraria montana var. lobata inhibited NO release in LPS-activated RAW264.7 cells, and compound 1 showed the most potent anti-inflammatory activity through modulating HSP90AA1/MAPK/mTOR/NF-κB signaling pathways.
- Formononetin from Pueraria montana var. lobata showed anti-inflammatory effects by modulating macrophage autophagy and polarization in vitro and in vivo, though findings are preliminary.
Frequently asked questions
What is Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South?
Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South (Pueraria montana var. lobata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South?
4 sourced findings are recorded for Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South; the strongest carries evidence grade D. For example: Pueraria montana var. lobata extract reduced lipid accumulation and inflammation in mice with diet-induced liver disease.
How strong is the evidence for Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South?
The strongest finding for Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South safe? What are the side effects?
No major safety issues are recorded for Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South interact with medications?
No drug interactions are recorded for Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South in our sources. This does not rule them out — check with a pharmacist.
Is Foot-a-night vine, Japanese arrowroot, Kudzu vine, Vine-that-ate-the-South a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 The Anti-Inflammatory Effects of Formononetin, an Active Constituent of Pueraria montana Var. Lobata, via Modulation of Macrophage Autophagy and Polarization. literature abstract metadata
- T2 Network pharmacology combines cellular experiments to investigate the anti-inflammatory phytochemicals of vine of Pueraria montana var. lobata and their mechanism. literature abstract metadata
- T2 Dual Action of Pueraria montana var. lobata Extract on Myogenesis and Muscle Atrophy. literature abstract metadata
- T2 Pueraria montana var. lobata Root Extract Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Increasing Mitochondrial β-Oxidation and Mitochondrial-Peroxisome Contact. literature abstract metadata