Sauropus spatulifolius
Sauropus spatulifolius
Sauropus spatulifolius is a plant traditionally unrecorded for medicinal use. Scientific evidence suggests potential anti-inflammatory and antioxidant properties, with studies indicating that its ethanol extract can reduce inflammation and oxidative stress in acute lung injury models by inhibiting NF-κB and activating Nrf2 pathways. Additionally, the plant contains 38 alkaloids, three of which showed α-glucosidase inhibitory activity. K3G from Sauropus spatulifolius also reduced pro-inflammatory cytokine release and mucus production in airway inflammation models by downregulating NOTCH pathway activation. The evolutionary history of Sauropus spatulifolius indicates it shares a common diploid ancestor with Phyllanthus emblica, suggesting shared genetic origins for some compounds. No significant safety concerns or recorded drug interactions have been identified to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The ethanol extract of Sauropus spatulifolius and its active constituents reduced inflammation and oxidative stress in LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation.
- The study identified 38 alkaloids from Sauropus spatulifolius leaves, three of which exhibited α-glucosidase inhibitory activity.
- K3G from Sauropus spatulifolius reduced pro-inflammatory cytokine release and mucus production by downregulating NOTCH pathway activation in airway inflammation models.
- The study revealed that Sauropus spatulifolius, along with Phyllanthus emblica, evolved through allopolyploidy from common diploid ancestors.
Frequently asked questions
What is Sauropus spatulifolius?
Sauropus spatulifolius (Sauropus spatulifolius) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Sauropus spatulifolius?
4 sourced findings are recorded for Sauropus spatulifolius; the strongest carries evidence grade D. For example: The ethanol extract of Sauropus spatulifolius and its active constituents reduced inflammation and oxidative stress in LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation.
How strong is the evidence for Sauropus spatulifolius?
The strongest finding for Sauropus spatulifolius carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Sauropus spatulifolius safe? What are the side effects?
No major safety issues are recorded for Sauropus spatulifolius in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Sauropus spatulifolius interact with medications?
No drug interactions are recorded for Sauropus spatulifolius in our sources. This does not rule them out — check with a pharmacist.
Is Sauropus spatulifolius a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Haplotype-resolved genomes of octoploid species in Phyllanthaceae family reveal a critical role for polyploidization and hybridization in speciation. literature abstract metadata
- T2 2-Acylpyrrole-based alkaloids from the leaves of Sauropus spatulifolius and their α-glucosidase inhibitory activities. literature abstract metadata
- T2 NOTCH pathway was involved in Kaempferol 3-O-gentiobioside attenuated airway inflammation and mucus hypersecretion. literature abstract metadata
- T2 Ethanol extract of Sauropus spatulifolius and its active constituents attenuate LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation. literature abstract metadata