Sauropus spatulifolius
Sauropus spatulifolius
Sauropus spatulifolius is a plant traditionally not associated with any specific medicinal uses. Scientific research has shown that its ethanol extract and certain active constituents can reduce inflammation and oxidative stress in LPS-induced acute lung injury by inhibiting NF-κB and activating Nrf2, indicating potential anti-inflammatory properties. Additionally, 38 alkaloids were identified from the leaves of Sauropus spatulifolius, with three exhibiting moderate α-glucosidase inhibitory activity, suggesting possible benefits for glycemic control. Another compound, K3G, was found to reduce pro-inflammatory cytokine release and mucus production by targeting the NOTCH pathway in both cell and animal models. The study also reconstructed the evolutionary history of Sauropus spatulifolius and Phyllanthus emblica, highlighting roles of polyploidization and hybridization in their speciation. To date, no major safety issues or drug interactions have been recorded for Sauropus spatulifolius.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The ethanol extract of Sauropus spatulifolius and its active constituents reduced inflammation and oxidative stress in LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation.
- The study identified 38 alkaloids from Sauropus spatulifolius leaves, three of which exhibited α-glucosidase inhibitory activity.
- K3G from Sauropus spatulifolius reduced pro-inflammatory cytokine release and mucus production by downregulating NOTCH pathway activation in airway inflammation models.
- The study revealed that Sauropus spatulifolius, along with Phyllanthus emblica, evolved through allopolyploidy from common diploid ancestors.
Frequently asked questions
What is Sauropus spatulifolius?
Sauropus spatulifolius (Sauropus spatulifolius) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Sauropus spatulifolius?
4 sourced findings are recorded for Sauropus spatulifolius; the strongest carries evidence grade D. For example: The ethanol extract of Sauropus spatulifolius and its active constituents reduced inflammation and oxidative stress in LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation.
How strong is the evidence for Sauropus spatulifolius?
The strongest finding for Sauropus spatulifolius carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Sauropus spatulifolius safe? What are the side effects?
No major safety issues are recorded for Sauropus spatulifolius in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Sauropus spatulifolius interact with medications?
No drug interactions are recorded for Sauropus spatulifolius in our sources. This does not rule them out — check with a pharmacist.
Is Sauropus spatulifolius a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Haplotype-resolved genomes of octoploid species in Phyllanthaceae family reveal a critical role for polyploidization and hybridization in speciation. literature abstract metadata
- T2 2-Acylpyrrole-based alkaloids from the leaves of Sauropus spatulifolius and their α-glucosidase inhibitory activities. literature abstract metadata
- T2 NOTCH pathway was involved in Kaempferol 3-O-gentiobioside attenuated airway inflammation and mucus hypersecretion. literature abstract metadata
- T2 Ethanol extract of Sauropus spatulifolius and its active constituents attenuate LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation. literature abstract metadata