FolkKB

Cryptolepis dubia

Cryptolepis dubia

Cryptolepis dubia is a plant traditionally used in some African herbal medicine practices, though specific uses are not well-documented. Scientific studies have identified several steroidal compounds from Cryptolepis dubia, with (-)-cryptanoside A showing potent cytotoxic and NKA inhibitory activities. Two leuconoxine-type diazaspiroindole alkaloids were also isolated, demonstrating selective cytotoxicity towards ovarian cancer cells. Four new pentacyclic triterpene glycosides from Cryptolepis buchananii fruits inhibited NO production in LPS-activated RAW264.7 cells. While (-)-cryptanoside A exhibited potent cytotoxicity against various human cancer cell lines, the evidence is limited and further research is needed to confirm these findings. No major safety issues or drug interactions have been recorded for Cryptolepis dubia, but caution should be exercised given its potential cytotoxic effects.

De un vistazo
Mejor evidencia
D
Precauciones
—

Solo información. El uso tradicional no significa eficacia probada. La evidencia y la seguridad varían — consulte las fuentes citadas.

Lo que dice la ciencia

  • Cryptolepis dubia produjo varios compuestos esteroideas, con (-)-cryptanosido A mostrando actividades citotóxicas y potentes inhibidoras de NKA. D PMID
  • Two leuconoxine-type diazaspiroindole alkaloids were isolated from Cryptolepis dubia and showed selective cytotoxicity towards OVCAR3 human ovarian cancer cells. D PMID
  • Se isolataron cuatro nuevos glicósidos triterpenoides pentacíclicos de las frutas de Cryptolepis buchananii y mostraron una inhibición significativa en la producción de NO en células RAW264.7 activadas con LPS. D PMID
  • (-)-Criptanosido A de Cryptolepis dubia mostró potente citotoxicidad contra varias líneas celulares cancerosas humanas con selectividad hacia las células cancerosas. D PMID

Frequently asked questions

What is Cryptolepis dubia?

Cryptolepis dubia (Cryptolepis dubia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Cryptolepis dubia?

4 sourced findings are recorded for Cryptolepis dubia; the strongest carries evidence grade D. For example: Cryptolepis dubia produjo varios compuestos esteroideas, con (-)-cryptanosido A mostrando actividades citotóxicas y potentes inhibidoras de NKA.

How strong is the evidence for Cryptolepis dubia?

The strongest finding for Cryptolepis dubia carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Cryptolepis dubia safe? What are the side effects?

No major safety issues are recorded for Cryptolepis dubia in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Cryptolepis dubia interact with medications?

No drug interactions are recorded for Cryptolepis dubia in our sources. This does not rule them out — check with a pharmacist.

Is Cryptolepis dubia a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Fuentes

  1. T2 The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. literature abstract metadata
  2. T2 Four New Pentacyclic Triterpene Glycosides Isolated from the Fruits of Cryptolepis buchananii R.Br. ex Roem. & Schult and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells. literature abstract metadata
  3. T2 Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia. literature abstract metadata
  4. T2 Cytotoxic and Noncytotoxic Steroidal Constituents of Cryptolepis dubia. literature abstract metadata