FolkKB

Cryptolepis dubia

Cryptolepis dubia

Cryptolepis dubia is a plant traditionally used in some African herbal medicine practices, though specific uses are not well-documented. Scientific studies have identified several steroidal compounds from Cryptolepis dubia, with (-)-cryptanoside A showing potent cytotoxic and NKA inhibitory activities. Two leuconoxine-type diazaspiroindole alkaloids were also isolated, demonstrating selective cytotoxicity towards ovarian cancer cells. Four new pentacyclic triterpene glycosides from Cryptolepis buchananii fruits inhibited NO production in LPS-activated RAW264.7 cells. While (-)-cryptanoside A exhibited potent cytotoxicity against various human cancer cell lines, the evidence is limited and further research is needed to confirm these findings. No major safety issues or drug interactions have been recorded for Cryptolepis dubia, but caution should be exercised given its potential cytotoxic effects.

En bref
Meilleure preuve
D
Précautions
—

Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.

Ce que dit la science

  • Cryptolepis dubia a produit plusieurs composés stéroïdiens, avec (-)-cryptanoside A montrant des activités cytotoxiques et fortes inhibitrices de l'activité NKA. D PMID
  • Two leuconoxine-type diazaspiroindole alkaloids were isolated from Cryptolepis dubia and showed selective cytotoxicity towards OVCAR3 human ovarian cancer cells. D PMID
  • Quatre nouveaux glycosides triterpènes pentacycliques ont été isolés des fruits de Cryptolepis buchananii et ont montré une inhibition significative de la production de NO dans les cellules RAW264.7 activées par LPS. D PMID
  • Le (-)-cryptanoside A de Cryptolepis dubia a montré une cytotoxicité importante contre plusieurs lignées cellulaires cancéreuses humaines avec une sélectivité pour les cellules cancéreuses. D PMID

Frequently asked questions

What is Cryptolepis dubia?

Cryptolepis dubia (Cryptolepis dubia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Cryptolepis dubia?

4 sourced findings are recorded for Cryptolepis dubia; the strongest carries evidence grade D. For example: Cryptolepis dubia a produit plusieurs composés stéroïdiens, avec (-)-cryptanoside A montrant des activités cytotoxiques et fortes inhibitrices de l'activité NKA.

How strong is the evidence for Cryptolepis dubia?

The strongest finding for Cryptolepis dubia carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Cryptolepis dubia safe? What are the side effects?

No major safety issues are recorded for Cryptolepis dubia in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Cryptolepis dubia interact with medications?

No drug interactions are recorded for Cryptolepis dubia in our sources. This does not rule them out — check with a pharmacist.

Is Cryptolepis dubia a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. literature abstract metadata
  2. T2 Four New Pentacyclic Triterpene Glycosides Isolated from the Fruits of Cryptolepis buchananii R.Br. ex Roem. & Schult and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells. literature abstract metadata
  3. T2 Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia. literature abstract metadata
  4. T2 Cytotoxic and Noncytotoxic Steroidal Constituents of Cryptolepis dubia. literature abstract metadata