Prune de Damas
Carissa carandas · Bengal-currants
Carissa carandas, commonly known as Indian laurel or karonda, originates from traditional medicine practices primarily in India and Sri Lanka. While its use is well-documented in local folk remedies for conditions such as skin diseases and digestive issues, there are no specific recorded traditions detailing its application. Scientific studies have shown promising results with Carissa carandas extract exhibiting significant in vitro anticancer activity against A549 NSCLC cells through multi-targeted mechanisms. Additionally, CeO2NPs from the plant alleviated liver fibrosis by modulating TGF-β/Smads and Nrf2/HO-1 signaling pathways in rats. Valtrate, another compound derived from Carissa carandas, demonstrated potential as a GGT inhibitor with in vitro activity against LNCaP cell lines. A 28-day sub-acute feeding trial indicated that both fruit powder and methanol extracts of the plant increased hematological parameters without causing toxicity in rats. No major safety issues or drug interactions have been recorded for Carissa carandas, but further research is needed to validate these findings and explore its broader therapeutic applications.
- Meilleure preuve
- D
- Précautions
- —
Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.
Ce que dit la science
- A 28-day sub-acute feeding trial with Carissa carandas fruit powder and methanol extracts showed significant increases in hemoglobin, hematocrit, and platelet counts without toxicological effects.
- The study found that valtrate, an identified compound from Carissa carandas, showed potential as a GGT inhibitor in vitro and through molecular docking, though further clinical investigation is required.
- L'UA de Carissa carandas a montré une activité anticancéreuse significative in vitro contre les cellules A549 NSCLC avec des effets multitarifs.
- CeO2NPs atténuent la fibrose hépatique en modulant les voies de signalisation TGF-β/Smads et Nrf2/HO-1 chez les rats.
Frequently asked questions
What is Prune de Damas?
Prune de Damas (Carissa carandas) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Prune de Damas?
4 sourced findings are recorded for Prune de Damas; the strongest carries evidence grade D. For example: A 28-day sub-acute feeding trial with Carissa carandas fruit powder and methanol extracts showed significant increases in hemoglobin, hematocrit, and platelet counts without toxicological effects.
How strong is the evidence for Prune de Damas?
The strongest finding for Prune de Damas carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Prune de Damas safe? What are the side effects?
No major safety issues are recorded for Prune de Damas in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Prune de Damas interact with medications?
No drug interactions are recorded for Prune de Damas in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Prune de Damas?
Prune de Damas is also known as: Bengal-currants, Каранда.
Is Prune de Damas a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Cerium oxide nanoparticles attenuate hepatic failure via blocking TGF-β/Smads and upregulating Nrf2/HO-1 signaling pathways in liver fibrosis rat model. literature abstract metadata
- T2 Antioxidant activity and in-silico evaluation of natural compounds of Carissa carandas as potential inhibitors of Gamma-Glutamyl Transpeptidase to enhance the efficacy of chemotherapy drugs against prostate cancer. literature abstract metadata
- T2 Ursolic acid from Carissa carandas L. as a multi-target agent against NSCLC: An Integrative in silico and in vitro study. literature abstract metadata
- T2 Carissa carandas L. and Its Methanol Extracts Promote Hematopoiesis and Thrombocytopoiesis: A Sub-Acute Toxicological Study in Experimental Rats. literature abstract metadata