Cissampelos pareira
Cissampelos pareira
Cissampelos pareira is a traditional medicinal plant primarily used in South American folk medicine, particularly among indigenous communities. While its specific uses are not well-documented, it has been studied for various bioactive compounds. Scientific research indicates the presence of bergenin and oleanolic acid, which have been quantified using validated HPLC methods. Additionally, nine new polyhydroxylated oleanane triterpenoids were isolated from Cissampelos pareira var. hirsuta, showing varying levels of cytotoxicity and nitric oxide inhibition. In silico modeling suggests that nuciferine may have potential therapeutic applications by targeting PTGS2, though further research is necessary to confirm these findings. The plant's endophytic fungal content varies with tissue type and cultivation method, some strains exhibiting α-glucosidase inhibitory activity. No major safety concerns or known drug interactions have been recorded for Cissampelos pareira.
- Meilleure preuve
- D
- Précautions
- —
Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.
Ce que dit la science
- Network analysis and in silico modeling suggest Nuciferine may target PTGS2, potentially benefiting diabetes management by modulating inflammatory processes.
- La richesse et la diversité des champignons endophytes dans Cissampelos pareira variaient selon les tissus végétaux et le mode d'culture, certaines souches montrant une activité inhibitrice de l'α-glucosidase.
- Un méthodologie validée HPTLC a été développée pour quantifier la bergenine et l'acide oléancier dans Cissampelos pareira et d'autres plantes.
- Neuf nouveaux triterpènes ont été identifiés chez Cissampelos pareira var. hirsuta, montrant des activités cytotoxiques et antiréaction inflammatoire variées.
Frequently asked questions
What is Cissampelos pareira?
Cissampelos pareira (Cissampelos pareira) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Cissampelos pareira?
4 sourced findings are recorded for Cissampelos pareira; the strongest carries evidence grade D. For example: Network analysis and in silico modeling suggest Nuciferine may target PTGS2, potentially benefiting diabetes management by modulating inflammatory processes.
How strong is the evidence for Cissampelos pareira?
The strongest finding for Cissampelos pareira carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Cissampelos pareira safe? What are the side effects?
No major safety issues are recorded for Cissampelos pareira in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Cissampelos pareira interact with medications?
No drug interactions are recorded for Cissampelos pareira in our sources. This does not rule them out — check with a pharmacist.
Is Cissampelos pareira a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Community Structure Diversity of Endophytic Fungi in Cissampelos pareira from Different Habitats and Their α-Glucosidase Inhibitory Activity. literature abstract metadata
- T2 Exploring the Potential of Nuciferine in Diabetes Management via PTGS2 Pathway Targeting by Network Analysis and in Silico Modeling Approach. literature abstract metadata
- T2 Cissatriterpenoids D-L, nine undescribed polyhydroxylated oleanane triterpenoids from Cissampelos pareira var. hirsuta. literature abstract metadata
- T2 Development and Validation of a High-Performance Thin-Layer Chromatography Method for Simultaneous Quantification of Bergenin and Oleanolic Acid in Pashanbhed, Lambadi and Kalipath. literature abstract metadata