FolkKB

Cissampelos pareira

Cissampelos pareira

Cissampelos pareira is a climbing shrub utilized in various traditional medicine systems. It is historically applied to treat wounds, snakebites, fever, boils, and diarrhea, as well as urogenital complaints, urinary stones, diabetes, hypertension, and edema. Scientific evidence is currently limited to preliminary studies; network analysis and in silico modeling suggest Nuciferine may target PTGS2 to potentially assist in diabetes management, while certain endophytic fungi from the plant show alpha-glucosidase inhibitory activity. Additionally, some identified triterpenoids exhibit varying cytotoxic and anti-inflammatory properties. No major safety issues or notable drug interactions are currently recorded.

At a glance
Traditionally for
snakebite · diuretic
Traditions
traditional · Ayurveda
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

Traditional use

  • snakebite traditional T3 DRDUKE
  • diuretic traditional T3 DRDUKE
  • fever traditional T3 DRDUKE
  • boils Ayurveda T3 DRDUKE
  • expectorant traditional T3 DRDUKE
  • bladder complaints traditional T3 DRDUKE
  • diabetes traditional T3 DRDUKE
  • diarrhea traditional T3 DRDUKE
  • dropsy (edema) traditional T3 DRDUKE
  • hypertension traditional T3 DRDUKE
  • palpitation traditional T3 DRDUKE
  • urinary stones traditional T3 DRDUKE
  • urogenital complaints traditional T3 DRDUKE
  • wounds Ayurveda T3 DRDUKE
  • anecbolic traditional T3 DRDUKE

What the science says

  • Network analysis and in silico modeling suggest Nuciferine may target PTGS2, potentially benefiting diabetes management by modulating inflammatory processes. D PMID
  • The richness and diversity of endophytic fungi in Cissampelos pareira varied by plant tissue and cultivation method, with some strains exhibiting α-glucosidase inhibitory activity. D PMID
  • A validated HPTLC method was developed to quantify bergenin and oleanolic acid in Cissampelos pareira and other plants. D PMID
  • Nine new triterpenoids were identified from Cissampelos pareira var. hirsuta, showing varying cytotoxic and anti-inflammatory activities. D PMID

Frequently asked questions

What is Cissampelos pareira?

Cissampelos pareira (Cissampelos pareira) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What is Cissampelos pareira traditionally used for?

Traditional sources record Cissampelos pareira for: snakebite, diuretic, fever, boils, expectorant, bladder complaints. This reflects traditional use, not a proven medical treatment.

Which traditions use Cissampelos pareira?

Cissampelos pareira appears in these traditions in our sources: traditional, Ayurveda.

What does the scientific evidence say about Cissampelos pareira?

4 sourced findings are recorded for Cissampelos pareira; the strongest carries evidence grade D. For example: Network analysis and in silico modeling suggest Nuciferine may target PTGS2, potentially benefiting diabetes management by modulating inflammatory processes.

How strong is the evidence for Cissampelos pareira?

The strongest finding for Cissampelos pareira carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Cissampelos pareira safe? What are the side effects?

No major safety issues are recorded for Cissampelos pareira in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Cissampelos pareira interact with medications?

No drug interactions are recorded for Cissampelos pareira in our sources. This does not rule them out — check with a pharmacist.

Is Cissampelos pareira a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T3 Dr. Duke's Ethnobotanical Database public domain (USDA ARS — attribute Dr. Duke's)
  2. T2 Community Structure Diversity of Endophytic Fungi in Cissampelos pareira from Different Habitats and Their α-Glucosidase Inhibitory Activity. literature abstract metadata
  3. T2 Exploring the Potential of Nuciferine in Diabetes Management via PTGS2 Pathway Targeting by Network Analysis and in Silico Modeling Approach. literature abstract metadata
  4. T2 Cissatriterpenoids D-L, nine undescribed polyhydroxylated oleanane triterpenoids from Cissampelos pareira var. hirsuta. literature abstract metadata
  5. T2 Development and Validation of a High-Performance Thin-Layer Chromatography Method for Simultaneous Quantification of Bergenin and Oleanolic Acid in Pashanbhed, Lambadi and Kalipath. literature abstract metadata